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June 1988

Plasma Monoamine Metabolites in Psychotic Disorders

Author Affiliations

From the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn.

Arch Gen Psychiatry. 1988;45(6):595-596. doi:10.1001/archpsyc.1988.01800300093014

The measurement of monoamine metabolites in the plasma of psychiatric patients is now possible thanks to methods that have become available over the past ten years.1.2 As was true to some degree for investigations in cerebrospinal fluid (CSF), clinical research using these measures in plasma has proceeded without full knowledge of their origin and significance.3 Currently, most investigators believe that both central and peripheral sources contribute to plasma homovanillic acid (HVA) and methoxyhydroxyphenylglycol (MHPG) metabolites of dopamine and norepinephine, respectively. Debrisoquin has been used in some studies in an effort to minimize the peripheral

See also pp 553, 561, and 564.

contribution to plasma monoamine metabolite values.4 Diet can be a major contributor to plasma HVA concentrations under certain circumstances,5 and diurnal changes have been noted.6

Despite incomplete information regarding the processes plasma monoamine metabolites may reflect, a number of interesting clinical findings have already

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