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October 1991

Evidence of Reduced Temporolimbic Structure Volumes in Schizophrenia

Arch Gen Psychiatry. 1991;48(10):956-957. doi:10.1001/archpsyc.1991.01810340088012

To the Editor.—  In the postmortem brain material of the Würzburg collection, Heckers et al1 found only a subtle trend toward volume reduction of the total left hippocampal formation in schizophrenic patients (-6%, P =.187). There were no significant volume changes in the right hippocampus or the right and left amygdala. In the same collection, no differences in the volumes of the parahippocampal gyrus were found.2 The authors believe the discrepancy with our previous findings of reduced hippocampal, amygdala, and parahippocampal gyrus volumes in schizophrenic persons are a result of methodologic shortcomings in our 1985 article.3 However, the results obtained from the material of the Würzburg collection1,2 are not only in contrast with our 1985 findings, they also refute six other postmortem studies4-9 that gave planimetric evidence of reduced parahippocampal gyrus4,6,7 or hippocampal5,8,9 size in schizophrenic patients. Moreover, according to the declared