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March 1992

Infants at Risk for Schizophrenia: Sequelae of a Genetic Neurointegrative Defect: A Review and Replication Analysis of Pandysmaturation in the Jerusalem Infant Development Study

Author Affiliations

From the Department of Psychiatry and Behavioral Science, the University of California at Los Angeles (Dr Fish); the Department of Psychiatry, University of Chicago (III) (Drs Marcus and Hans); the Department of Psychology, Hebrew University of Jerusalem (Israel) (Dr Auerbach); and the University of Texas Health Science Center at San Antonio (Dr Perdue).

Arch Gen Psychiatry. 1992;49(3):221-235. doi:10.1001/archpsyc.1992.01820030053007

• A 1975 report stated that a schizophrenic genotype may be manifested in infants by a neurointegrative defect called pandysmaturation. Recent evidence supports this: (1) 12 studies found delayed development in schizophrenics' infants and in preschizophrenics; (2) "blind" psychometric evaluations favored an adult schizotypal disorder in four to six of seven high-risk subjects with pandysmaturation in the New York study; and (3) finally, in a partial replication of this method using the Jerusalem data, blind diagnoses of "probable" and "possible" pandysmaturation were significantly related to a parental diagnosis of schizophrenia and to cognitive and motor neurointegrative deficits at 10 years. Obstetrical complications were unrelated to diagnosis, pandysmaturation, or outcome in the overall sample. However, we found a small subgroup of schizophrenic offspring in whom the most severe motor deficits at follow-up were related to obstetrical complications, pandysmaturation, and low birth weight.

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