Drs Vita and Sacchetti raise a number of interesting issues with respect to the generalizability of our findings of familial and obstetric influences on ventricular and sulcal enlargement in the Copenhagen High-risk Project sample.1 Their central concern appears to be that associations between these variables in a group of affected and unaffected individuals with schizophrenic first-degree relatives are not necessarily representative of their associations in the population of schizophrenic patients as a whole. While we certainly agree that generalizability in this context is an important issue that remains to be quantified, we disagree with these authors' interpretation of the findings that are cited in favor of nonrepresentativeness.First, it is important to note that most of the previous studies that have investigated associations between familial risk for schizophrenia and ventricular enlargement have compared morphologic measures among patients with and without a positive FH of the disorder. The results of these
Cannon TD, Mednick SA, Parnas J, Schulsinger F, Praesthold J, Vestergaard A. Developmental Brain Abnormalities in Schizophrenia: Contributions of Genetic and Perinatal Factors-Reply. Arch Gen Psychiatry. 1995;52(2):157–159. doi:10.1001/archpsyc.1995.03950140075014
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