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April 1995

In Pursuit of the Molecular Neuropathology of Schizophrenia

Author Affiliations

Departments of Pathology and Laboratory Medicine and Psychiatry University of Pennsylvania School of Medicine HUP/Maloney, Room A009 36th and Spruce streets Philadelphia, PA 19104-4283

Arch Gen Psychiatry. 1995;52(4):274-276. doi:10.1001/archpsyc.1995.03950160024005

The search for the defining neuropathological features of schizophrenia continues to be one of the highest priority areas of research on this severely debilitating and very common neuropsychiatric disorder (for recent updates and comprehensive reviews of previous studies of the regional neuropathology of schizophrenia as well as an extensive compilation of the pertinent more general literature on this subject, see Carpenter and Buchanan,1 Kerwin,2 Shapiro,3 and Winn4). There are a number of compelling reasons that justify intense research efforts to delineate the central nervous system (CNS) lesions that constitute a primary "cause" of schizophrenia as well as those secondary events that underlie the varied behavioral symptoms of this highly complex disease. Specifically, the identification of such lesions would markedly enhance the pace of research on schizophrenia by enabling investigators to (1) generate testable hypotheses about the cause and molecular pathogenesis of this disorder; (2) develop specific