Waddington and his colleagues take us to task for omitting to refer to their recent work on the topic of the general population rate of schizophrenia in Ireland. We regret this omission, the more so as their findings are confirmatory of our own work on the same topic.They rightly point out that overall general population rates may obscure pockets of high incidence and/or prevalence in localized areas and they note their own findings in an Irish county in this regard. However, observations of this kind on a microscale may throw up variations between contiguous regions of small population size simply by chance, as has been pointed out by Lin and Goodman1 in this journal when commenting on the original presentation by Youssef and colleagues.2 An additional difficulty arises with the diagnostic cross-reliability between studies, although this of course is not relevant to the interregional variation observed in the
Walsh D, Kendler KS. The Prevalence of Schizophrenia in Ireland: Readdressing the Enigma-Reply. Arch Gen Psychiatry. 1995;52(6):509. doi:10.1001/archpsyc.1995.03950180095015
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