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October 1995

Neocortical Abnormalities in Schizophrenia

Author Affiliations

Department of Psychiatry and Mental Health Research Institute University of Michigan 205 Zina Pitcher Pl Ann Arbor, MI 48109-0720

Arch Gen Psychiatry. 1995;52(10):819-820. doi:10.1001/archpsyc.1995.03950220029006

The HISTORY of the study of brains of individuals with schizophrenia is replete with novel, fragmentary, and even occasionally enticing findings, if any positive results were obtained at all. Most of these findings have proved to be elusive when replications have been attempted. In fact, the most consistent finding in studies of the brains of persons with schizophrenia is that they are usually not distinguishable from the brains of normal individuals. However, over the last 15

See also page 805 years, a literature has been slowly accumulating in two scientific arenas, structural brain imaging and functional brain imaging. Studies of the structure of schizophrenic brains (via computed tomographic or magnetic resonance imaging scans) have produced a subtle but increasingly reliable set of observations. Such studies have often pointed toward ventricular enlargement, sulcal widening, and cortical atrophy, with occasional suggestions of left temporal lobe, frontal lobe, and thalamic atrophy.1-4 Functional

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