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December 1995

Response to Commentaries and to the Challenge of Building a Perfect Theory to Explain Schizophrenia

Author Affiliations

Department of Psychiatry Washington University School of Medicine 4940 Children's Pl Campus Box 8143 St Louis, MO 63110-1093

Arch Gen Psychiatry. 1995;52(12):1019-1024. doi:10.1001/archpsyc.1995.03950240037008

RESPONSE TO DR BENES' COMMENTARY  When we wrote our original article we felt constrained to limit speculation to a bare minimum. In developing our response to the commentaries of Benes, Henn, and Crow, it became evident that such constraint would be inappropriate. Their insightful, challenging, and sometimes provocative comments, especially those of Dr Crow, inspired us to expand our hypothesis well beyond its empirical base. Accordingly, our response reflects an effort to expand our hypothesis in speculative directions necessary to make it competitive with other theories (reviewed by Crow) dedicated to the worthy but elusive goal of explaining all aspects of schizophrenia.

See also pages 998, 1008, 1011, and 1015  Benes1 examines potential parallels between the schizophrenia model we have developed based on animal studies2 and a model she has developed based on postmortem histological examination of the brains of schizophrenic patients. We agree that there are some

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