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July 1996

Mapping Mental IllnessA New Era

Author Affiliations

Director of Brain Mapping Department of Neurology UCLA School of Medicine 710 Westwood Plaza, Room 1-240 Los Angeles, CA 90095

Arch Gen Psychiatry. 1996;53(7):574-576. doi:10.1001/archpsyc.1996.01830070016004

Where the telescope ends, the microscope begins. Which of the two has the grander view?

Les Miserables, Victor Hugo, 1862

THIS ISSUE of the Archives reflects the explosion of neuroimaging technologies and their application to clinical neuroscience, in this case, to the study of mental illness. Since the invention of x-ray computed tomography 20 years ago,1 a progressive array of constantly improving structural and functional imaging techniques has been developed to study the human brain in vivo. The modern structural imaging methods include x-ray computed tomography, magnetic resonance imaging, and magnetic resonance angiography. As discussed in several articles in this issue,2-7 these techniques are of increasing value for investigating the morphometric structure of the human brain when it is healthy and diseased. Functional human brain imaging methods include single photon emission computed tomography, positron emission tomography, functional magnetic resonance imaging, magnetic resonance spectroscopy, optical intrinsic signal imaging, electroencephalography, and magnetoencephalography. These techniques provide

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