In a contribution to the January 1995 issue of the Archives comparing the efficacy and tolerability of clomipramine, fluoxetine, fluvoxamine, and sertraline, Greist et al,1 using a method of meta-analysis, found all 4 agents to be effective in the treatment of patients who have obsessive-compulsive disorder (OCD). Whereas all 4 are serotonin-transport inhibitors, clomipramine, with its noradrenergic transport—inhibition component, most notably showed an efficacy advantage. With regard to this finding, Greist et al stated, "It seems that something may be missing in fluoxetine, fluvoxamine, and sertraline that clomipramine contains." They posed the question, "Will agents such as... venlafaxine hydrochloride, which have selective and potent serotonin and noradrenergic transport inhibition and a better side-effect profile than clomipramine, work well in treating OCD?" I wish to respond by reporting our limited experience with venlafaxine therapy in such patients. Research that we have conducted suggests that the preliminary answer to this
Yaryura-Tobias JA, Neziroglu FA. Venlafaxine in Obsessive-compulsive Disorder. Arch Gen Psychiatry. 1996;53(7):653–654. doi:10.1001/archpsyc.1996.01830070103016
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