This is an interesting and informative case report that demonstrates changes in brain membrane phospholipid metabolism in a young subject with HD. The changes observed in the subject with HD are similar to the changes previously reported in subjects with schizophrenia.1-3 The in vivo31P MRS findings in the subject with HD are consistent with earlier in vitro31P MRS findings on autopsy brain samples of subjects with HD that revealed changes in membrane phospholipid metabolism.4 The young subject with HD had clinical and molecular features that were similar to young subjects with schizophrenia.
The findings of decreased phosphomonoester concentrations in this subject with HD and the previously reported subjects with schizophrenia probably reflect changes in the neuropil. These changes could be due to the following: (1) reduced neuropil development (ie, an early neurodevelopmental insult), (2) exaggerated synaptic pruning of a normal neuropil (ie, a late
Pettegrew JW, Keshavan MS. Phosphorus 31 Magnetic Resonance Spectroscopy in Patients With Huntington Disease-Reply. Arch Gen Psychiatry. 1997;54(2):187–188. doi:10.1001/archpsyc.1997.01830140099017
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