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June 1997

N-Methyl-D-Aspartate Receptor Hypofunction in Schizophrenia Could Arise From Reduced Cortical Connectivity Rather Than Receptor Dysfunction-Reply

Author Affiliations

Department of Psychiatry Washington University School of Medicine 4940 Children's Place St Louis, MO 63110

Arch Gen Psychiatry. 1997;54(6):579-580. doi:10.1001/archpsyc.1997.01830180097018

Hoffman and McGlashan are generally accepting of our NMDA receptor hypofunction (NRH) hypothesis of schizophrenia, but they argue that NRH could arise from reduced cortical connectivity rather than receptor dysfunction per se, and in their closing paragraphs they introduce a neurodevelopmental twist (faulty synaptic pruning) that they would like to see emphasized in an alternate framing of our hypothesis.

Implicit in their letter is the suggestion that reduced cortical connectivity, faulty synaptic pruning, and a neu

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