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In a 5-year longitudinal study comparing the change in cortical thickness in schizophrenic patients and healthy subjects, van Haren et alArticle found excessive thinning over time in widespread areas of the brain, most pronounced bilaterally in the temporal cortex and in the left frontal area and progressing across the entire course of the illness. The excessive thinning of the cortex appears related to outcome and cumulative antipsychotic medication intake.
In a multimodal imaging study, Fusar-Poli et alArticle investigated subjects at clinical risk for psychosis and matched controls using functional magnetic resonance imaging while performing a verbal fluency task and proton magnetic resonance spectroscopy to measure brain regional glutamate levels. They found that altered prefrontal, hippocampal, and temporal function in subjects at high risk for psychosis is related to a reduction in thalamic glutamate levels, and this relationship is different from that in healthy controls.
This Month in Archives of General Psychiatry. Arch Gen Psychiatry. 2011;68(9):868. doi:10.1001/archgenpsychiatry.2011.102
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