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Kraemer et al Article suggest that, as important as it is to establish whether a treatment is effective in a randomized clinical trial, it is almost as vital to understand on whom treatments work or do not (moderators), and why treatments work or do not(mediators). This report suggests analytic strategies by which moderators and mediators of a treatment might be sought in exploratory or hypothesis-generating activities after completion of a randomized clinical trial, and urges that such analyses follow every randomized clinical trial.
Currently the biological basis of Asperger syndrome is unknown. Thus Murphy et al Article used in vivo 1H-magnetic resonance spectroscopy (1H-MRS) to examine the neuronal integrity of adults with Asperger syndrome and controls. People with Asperger syndrome had a significantly higher prefrontal lobe concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline. Metabolite differences were significantly correlated with obsessional behavior and social abnormalities. These data suggest that clinical symptoms in people with Asperger syndrome are caused by abnormalities in programmed cell death and metabolism.
This Month in Archives of General Psychiatry. Arch Gen Psychiatry. 2002;59(10):872–873. doi:10.1001/archpsyc.59.10.872
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