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1.
Mathers  CDLoncar  D Projections of global mortality and burden of disease from 2002 to 2030.  PLoS Med2006311e442PubMedGoogle Scholar
2.
Murray  CJLopez  AD Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study.  Lancet1997349906414981504PubMedGoogle Scholar
3.
 Obesity and overweight.  WHO Web site. http://www.who.int/dietphysicalactivity/publications/facts/obesity/en/. Accessed February 9, 2009
4.
Penninx  BWBeekman  ATHonig  ADeeg  DJSchoevers  RAvan Eijk  JTvan Tilburg  W Depression and cardiac mortality: results from a community-based longitudinal study.  Arch Gen Psychiatry2001583221227PubMedGoogle Scholar
5.
de Wit  LMvan Straten  Avan Herten  MPenninx  BWCuijpers  P Depression and body mass index, a u-shaped association.  BMC Public Health2009914PubMedGoogle Scholar
6.
Faith  MSMatz  PEJorge  MA Obesity-depression associations in the population.  J Psychosom Res2002534935942PubMedGoogle Scholar
7.
Scott  KM McGee  MAWells  JEOakley Browne  MA Obesity and mental disorders in the adult general population.  J Psychosom Res200864197105PubMedGoogle Scholar
8.
Atlantis  EBaker  M Obesity effects on depression: systematic review of epidemiological studies.  Int J Obes (Lond)2008326881891PubMedGoogle Scholar
9.
de Wit  LMLuppino  FSvan Straten  ACuijpers  P Obesity and depression: a meta-analysis of community based studies.  Psychiatry Res In press Google Scholar
10.
Stunkard  AJFaith  MSAllison  KC Depression and obesity.  Biol Psychiatry2003543330337PubMedGoogle Scholar
11.
Bornstein  SRSchuppenies  AWong  MLLicinio  J Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interactions.  Mol Psychiatry20061110892902PubMedGoogle Scholar
12.
Herva  ALaitinen  JMiettunen  JVeijola  JKarvonen  JTLaksy  KJoukamaa  M Obesity and depression: results from the longitudinal Northern Finland 1966 Birth Cohort Study.  Int J Obes (Lond)2006303520527PubMedGoogle Scholar
13.
Roberts  REKaplan  GAShema  SJStrawbridge  WJ Are the obese at greater risk for depression?  Am J Epidemiol20001522163170PubMedGoogle Scholar
14.
Roberts  REStrawbridge  WJDeleger  SKaplan  GA Are the fat more jolly?  Ann Behav Med2002243169180PubMedGoogle Scholar
15.
Roberts  REDeleger  SStrawbridge  WJKaplan  GA Prospective association between obesity and depression: evidence from the Alameda County Study.  Int J Obes Relat Metab Disord2003274514521PubMedGoogle Scholar
16.
Bardone  AMMoffitt  TECaspi  ADickson  NStanton  WRSilva  PA Adult physical health outcomes of adolescent girls with conduct disorder, depression, and anxiety.  J Am Acad Child Adolesc Psychiatry1998376594601PubMedGoogle Scholar
17.
Barefoot  JCHeitmann  BLHelms  MJWilliams  RBSurwit  RSSiegler  IC Symptoms of depression and changes in body weight from adolescence to mid-life.  Int J Obes Relat Metab Disord1998227688694PubMedGoogle Scholar
18.
Hasler  GPine  DSKleinbaum  DGGamma  ALuckenbaugh  DAjdacic  VEich  DRossler  WAngst  J Depressive symptoms during childhood and adult obesity: the Zurich Cohort Study.  Mol Psychiatry2005109842850PubMedGoogle Scholar
19.
Pine  DSCohen  PBrook  JCoplan  JD Psychiatric symptoms in adolescence as predictors of obesity in early adulthood: a longitudinal study.  Am J Public Health199787813031310PubMedGoogle Scholar
20.
Pine  DSGoldstein  RBWolk  SWeissman  MM The association between childhood depression and adulthood body mass index.  Pediatrics2001107510491056PubMedGoogle Scholar
21.
Richardson  LPDavis  RPoulton  R McCauley  EMoffitt  TECaspi  AConnell  F A longitudinal evaluation of adolescent depression and adult obesity.  Arch Pediatr Adolesc Med20031578739745PubMedGoogle Scholar
22.
Anderson  SECohen  PNaumova  ENJacques  PFMust  A Adolescent obesity and risk for subsequent major depressive disorder and anxiety disorder: prospective evidence.  Psychosom Med2007698740747PubMedGoogle Scholar
23.
Bjerkeset  ORomundstad  PEvans  JGunnell  D Association of adult body mass index and height with anxiety, depression, and suicide in the general population: the HUNT study.  Am J Epidemiol20081672193202PubMedGoogle Scholar
24.
Kasen  SCohen  PChen  HMust  A Obesity and psychopathology in women: a three decade prospective study.  Int J Obes (Lond)2008323558566PubMedGoogle Scholar
25.
Koponen  HJokelainen  JKeinanen-Kiukaanniemi  SKumpusalo  EVanhala  M Metabolic syndrome predisposes to depressive symptoms: a population-based 7-year follow-up study.  J Clin Psychiatry2008692178182PubMedGoogle Scholar
26.
Sachs-Ericsson  NBurns  ABGordon  KHEckel  LAWonderlich  SACrosby  RDBlazer  DG Body mass index and depressive symptoms in older adults: the moderating roles of race, sex, and socioeconomic status.  Am J Geriatr Psychiatry2007159815825PubMedGoogle Scholar
27.
van Gool  CHKempen  GIBosma  Hvan Boxtel  MPJolles  Jvan Eijk  JT Associations between lifestyle and depressed mood: longitudinal results from the Maastricht Aging Study.  Am J Public Health2007975887894PubMedGoogle Scholar
28.
Vogelzangs  NKritchevsky  SBBeekman  ATNewman  ABSatterfield  SSimonsick  EMYaffe  KHarris  TBPenninx  BW Depressive symptoms and change in abdominal obesity in older persons.  Arch Gen Psychiatry2008651213861393PubMedGoogle Scholar
29.
Joshi  AVDay  DLubowski  TJAmbegaonkar  A Relationship between obesity and cardiovascular risk factors: findings from a multi-state screening project in the United States.  Curr Med Res Opin2005211117551761PubMedGoogle Scholar
30.
Kenchaiah  SEvans  JCLevy  DWilson  PWBenjamin  EJLarson  MGKannel  WBVasan  RS Obesity and the risk of heart failure.  N Engl J Med20023475305313PubMedGoogle Scholar
31.
Kuijpers  Tvan der Windt  DAvan der Heijden  GJBouter  LM Systematic review of prognostic cohort studies on shoulder disorders.  Pain20041093420431PubMedGoogle Scholar
32.
Van der Kooy  Kvan Hout  HMarwijk  HMarten  HStehouwer  CBeekman  A Depression and the risk for cardiovascular diseases: systematic review and meta analysis.  Int J Geriatr Psychiatry2007227613626PubMedGoogle Scholar
33.
Borenstein  MHedges  LHiggins  JRothstein  H Comprehensive Meta-analysis [computer program].  Version 2. Englewood, NJ: Biostat; 2005
34.
Lipsey  MWWilson  DB Practical Meta-Analysis.  Thousand Oaks, CA: SAGE Publications Inc; 2001
35.
Higgins  JPThompson  SGDeeks  JJAltman  DG Measuring inconsistency in meta-analyses.  BMJ20033277414557560PubMedGoogle Scholar
36.
Rothstein  HSutton  AJBorenstein  M Publication Bias in Meta-analysis: Prevention, Assessment and Adjustments.  Hoboken, NJ: John Wiley & Sons Inc; 2005
37.
Egger  MDavey Smith  GSchneider  MMinder  C Bias in meta-analysis detected by a simple, graphical test.  BMJ19973157109629634PubMedGoogle Scholar
38.
Borenstein  MHedges  LVHiggins  JRothstein  H Introduction to Meta-Analysis.  Hoboken, NJ: John Wiley & Sons Inc; 2009
39.
Duval  STweedie  R Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.  Biometrics2000562455463PubMedGoogle Scholar
40.
Laumann  EOKang  JHGlasser  DBRosen  RCCarson  CC Lower urinary tract symptoms are associated with depressive symptoms in white, black and Hispanic men in the United States.  J Urol20081801233240PubMedGoogle Scholar
41.
Anderson  SECohen  PNaumova  ENMust  A Association of depression and anxiety disorders with weight change in a prospective community-based study of children followed up into adulthood.  Arch Pediatr Adolesc Med20061603285291PubMedGoogle Scholar
42.
Forman-Hoffman  VLYankey  JWHillis  SLWallace  RBWolinsky  FD Weight and depressive symptoms in older adults: direction of influence?  J Gerontol B Psychol Sci Soc Sci2007621S43S51PubMedGoogle Scholar
43.
Franko  DLStriegel-Moore  RHThompson  DSchreiber  GBDaniels  SR Does adolescent depression predict obesity in black and white young adult women?  Psychol Med2005351015051513PubMedGoogle Scholar
44.
 BMI classification.  WHO Global Database on Body Mass Index Web site. http://apps.who.int/bmi/index.jsp?introPage=intro_3.html. Accessed February 9, 2009
45.
Bean  MKStewart  KOlbrisch  ME Obesity in America: implications for clinical and health psychologists.  J Clin Psychol Med Settings2008153214224PubMedGoogle Scholar
46.
Emery  CFFondow  MDSchneider  CMChristofi  FLHunt  CBusby  AKNeedleman  BJMelvin  WSElsayed-Awad  HM Gastric bypass surgery is associated with reduced inflammation and less depression: a preliminary investigation.  Obes Surg2007176759763PubMedGoogle Scholar
47.
Shoelson  SEHerrero  LNaaz  A Obesity, inflammation, and insulin resistance.  Gastroenterology2007132621692180PubMedGoogle Scholar
48.
Vaccarino  VJohnson  BDSheps  DSReis  SEKelsey  SFBittner  VRutledge  TShaw  LJSopko  GBairey Merz  CNNational Heart, Lung, and Blood Institute Depression, inflammation, and incident cardiovascular disease in women with suspected coronary ischemia: the National Heart, Lung, and Blood Institute-sponsored WISE study.  J Am Coll Cardiol2007502120442050PubMedGoogle Scholar
49.
Bremmer  MABeekman  ATDeeg  DJPenninx  BWDik  MGHack  CEHoogendijk  WJ Inflammatory markers in late-life depression: results from a population-based study.  J Affect Disord20081063249255PubMedGoogle Scholar
50.
Milaneschi  YCorsi  AMPenninx  BWBandinelli  SGuralnik  JMFerrucci  L Interleukin-1 receptor antagonist and incident depressive symptoms over 6 years in older persons: the InCHIANTI Study.  Biol Psychiatry20096511973978PubMedGoogle Scholar
51.
Pasquali  RVicennati  V Activity of the hypothalamic-pituitary-adrenal axis in different obesity phenotypes.  Int J Obes Relat Metab Disord200024(suppl 2)S47S49PubMedGoogle Scholar
52.
Walker  BR Activation of the hypothalamic-pituitary-adrenal axis in obesity: cause or consequence?  Growth Horm IGF Res200111(suppl A)S91S95PubMedGoogle Scholar
53.
Belanoff  JKKalehzan  MSund  BFleming Ficek  SKSchatzberg  AF Cortisol activity and cognitive changes in psychotic major depression.  Am J Psychiatry20011581016121616PubMedGoogle Scholar
54.
Holsboer  F The corticosteroid receptor hypothesis of depression.  Neuropsychopharmacology2000235477501PubMedGoogle Scholar
55.
Lee  WJLee  YCSer  KHChen  JCChen  SC Improvement of insulin resistance after obesity surgery: a comparison of gastric banding and bypass procedures.  Obes Surg200818911191125PubMedGoogle Scholar
56.
Huber  JD Diabetes, cognitive function, and the blood-brain barrier.  Curr Pharm Des2008141615941600PubMedGoogle Scholar
57.
Ajilore  OHaroon  EKumaran  SDarwin  CBinesh  NMintz  JMiller  JThomas  MAKumar  A Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy.  Neuropsychopharmacology200732612241231PubMedGoogle Scholar
58.
Atlantis  EBall  K Association between weight perception and psychological distress.  Int J Obes (Lond)2008324715721PubMedGoogle Scholar
59.
Derenne  JLBeresin  EV Body image, media, and eating disorders.  Acad Psychiatry2006303257261PubMedGoogle Scholar
60.
Hoek  HWvan Harten  PNHermans  KMKatzman  MAMatroos  GESusser  ES The incidence of anorexia nervosa on Curacao.  Am J Psychiatry20051624748752PubMedGoogle Scholar
61.
Beesdo  KJacobi  FHoyer  JLow  NCHofler  MWittchen  HU Pain associated with specific anxiety and depressive disorders in a nationally representative population sample [published online April 10, 2009].  Soc Psychiatry Psychiatr EpidemiolPubMeddoi:10.1007/s00127-009-0045-1Google Scholar
62.
Gadalla  TPiran  N Psychiatric comorbidity in women with disordered eating behavior: a national study.  Women Health2008484467484PubMedGoogle Scholar
63.
 WHO Global InfoBase team.  Comparison BMI levels between countries. The SuRF Report2. http://apps.who.int/infobase/comparestart.aspx. Accessed February 9, 2009
64.
Björntorp  P Do stress reactions cause abdominal obesity and comorbidities?  Obes Rev2001227386PubMedGoogle Scholar
65.
Björntorp  P The regulation of adipose tissue distribution in humans.  Int J Obes Relat Metab Disord1996204291302PubMedGoogle Scholar
Meta-analysis
March 2010

Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies

Author Affiliations

Authors Affiliations: Departments of Psychiatry (Drs Luppino, Penninx, and Zitman) and Medical Statistics and Bioinformatics (Dr Stijnen), Leiden University Medical Center, and GGZ Rivierduinen (Drs Luppino, Penninx, and Zitman), Leiden, Department of Clinical Psychology, VU University (Ms de Wit and Dr Cuijpers), and Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center (Dr Penninx), Amsterdam, Department of Psychiatry, Erasmus Medical Centre, Rotterdam (Dr Bouvy), and Department of Psychiatry, University Medical Center Groningen, Groningen (Dr Penninx), the Netherlands.

Arch Gen Psychiatry. 2010;67(3):220-229. doi:10.1001/archgenpsychiatry.2010.2
Abstract

Context  Association between obesity and depression has repeatedly been established. For treatment and prevention purposes, it is important to acquire more insight into their longitudinal interaction.

Objective  To conduct a systematic review and meta-analysis on the longitudinal relationship between depression, overweight, and obesity and to identify possible influencing factors.

Data Sources  Studies were found using PubMed, PsycINFO, and EMBASE databases and selected on several criteria.

Study Selection  Studies examining the longitudinal bidirectional relation between depression and overweight (body mass index 25-29.99) or obesity (body mass index ≥30) were selected.

Data Extraction  Unadjusted and adjusted odds ratios (ORs) were extracted or provided by the authors.

Data Synthesis  Overall, unadjusted ORs were calculated and subgroup analyses were performed for the 15 included studies (N = 58 745) to estimate the effect of possible moderators (sex, age, depression severity). Obesity at baseline increased the risk of onset of depression at follow-up (unadjusted OR, 1.55; 95% confidence interval [CI], 1.22-1.98; P < .001). This association was more pronounced among Americans than among Europeans (P = .05) and for depressive disorder than for depressive symptoms (P = .05). Overweight increased the risk of onset of depression at follow-up (unadjusted OR, 1.27; 95% CI, 1.07-1.51; P < .01). This association was statistically significant among adults (aged 20-59 years and ≥60 years) but not among younger persons (aged <20 years). Baseline depression (symptoms and disorder) was not predictive of overweight over time. However, depression increased the odds for developing obesity (OR, 1.58; 95% CI, 1.33-1.87; P < .001). Subgroup analyses did not reveal specific moderators of the association.

Conclusions  This meta-analysis confirms a reciprocal link between depression and obesity. Obesity was found to increase the risk of depression, most pronounced among Americans and for clinically diagnosed depression. In addition, depression was found to be predictive of developing obesity.

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