Efficacy of Integrated Exposure Therapy vs Integrated Coping Skills Therapy for Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: A Randomized Clinical Trial | Psychiatry | JAMA Psychiatry | JAMA Network
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Figure 1.  Consort Flow Diagram
Consort Flow Diagram

I-CS indicates integrated coping skills; I-PE, integrated prolonged exposure; and PTSD, posttraumatic stress disorder.

Figure 2.  Posttraumatic Stress Disorder Symptom Severity Estimated Means by Treatment Condition at Each Time Point
Posttraumatic Stress Disorder Symptom Severity Estimated Means by Treatment Condition at Each Time Point

Error bars indicate 95% CIs. CAPS-5 indicates Clinician Administered PTSD Scale for DSM-5. I-CS indicates integrated coping skills; I-PE, integrated prolonged exposure.

Figure 3.  Exploratory Completer Analysis of Rates of Posttraumatic Stress Disorder (PTSD) Remission by Treatment Condition at Each Time Point
Exploratory Completer Analysis of Rates of Posttraumatic Stress Disorder (PTSD) Remission by Treatment Condition at Each Time Point

PTSD remission was defined as a Clinician Administered PTSD Scale for DSM-5 score less than 12. I-CS indicates integrated coping skills; I-PE, integrated prolonged exposure.

Table 1.  Demographic Characteristics of the Intention-to-Treat Samplea
Demographic Characteristics of the Intention-to-Treat Samplea
Table 2.  Continuous Outcomes at All Time Points
Continuous Outcomes at All Time Points
1.
Kessler  RC, Chiu  WT, Demler  O, Merikangas  KR, Walters  EE.  Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.  Arch Gen Psychiatry. 2005;62(6):617-627. doi:10.1001/archpsyc.62.6.617PubMedGoogle ScholarCrossref
2.
Seal  KH, Cohen  G, Waldrop  A, Cohen  BE, Maguen  S, Ren  L.  Substance use disorders in Iraq and Afghanistan veterans in VA healthcare, 2001-2010: implications for screening, diagnosis and treatment.  Drug Alcohol Depend. 2011;116(1-3):93-101. doi:10.1016/j.drugalcdep.2010.11.027PubMedGoogle ScholarCrossref
3.
Driessen  M, Schulte  S, Luedecke  C,  et al; TRAUMAB-Study Group.  Trauma and PTSD in patients with alcohol, drug, or dual dependence: a multi-center study.  Alcohol Clin Exp Res. 2008;32(3):481-488. doi:10.1111/j.1530-0277.2007.00591.xPubMedGoogle ScholarCrossref
4.
Tate  SR, Norman  SB, McQuaid  JR, Brown  SA.  Health problems of substance-dependent veterans with and those without trauma history.  J Subst Abuse Treat. 2007;33(1):25-32. doi:10.1016/j.jsat.2006.11.006PubMedGoogle ScholarCrossref
5.
Calabrese  JR, Prescott  M, Tamburrino  M,  et al.  PTSD comorbidity and suicidal ideation associated with PTSD within the Ohio Army National Guard.  J Clin Psychiatry. 2011;72(8):1072-1078. doi:10.4088/JCP.11m06956PubMedGoogle ScholarCrossref
6.
Edens  EL, Kasprow  W, Tsai  J, Rosenheck  RA.  Association of substance use and VA service-connected disability benefits with risk of homelessness among veterans.  Am J Addict. 2011;20(5):412-419. doi:10.1111/j.1521-0391.2011.00166.xPubMedGoogle ScholarCrossref
7.
Straus  E, Norman  SB, Haller  M, Southwick  SM, Hamblen  JL, Pietrzak  RH.  Differences in protective factors among U.S. Veterans with posttraumatic stress disorder, alcohol use disorder, and their comorbidity: results from the National Health and Resilience in Veterans Study.  Drug Alcohol Depend. 2019;194:6-12. doi:10.1016/j.drugalcdep.2018.09.011PubMedGoogle ScholarCrossref
8.
Foa  E, Hembree  E, Rothbaum  BO.  Prolonged Exposure Therapy for PTSD: Emotional Processing of Traumatic Experiences Therapist Guide. New York, NY: Oxford University Press; 2007. doi:10.1093/med:psych/9780195308501.001.0001
9.
Foa  EB, Dancu  CV, Hembree  EA, Jaycox  LH, Meadows  EA, Street  GP.  A comparison of exposure therapy, stress inoculation training, and their combination for reducing posttraumatic stress disorder in female assault victims.  J Consult Clin Psychol. 1999;67(2):194-200. doi:10.1037/0022-006X.67.2.194PubMedGoogle ScholarCrossref
10.
Institute of Medicine.  Treatment of Posttraumatic Stress Disorder: An Assessment of the Evidence. Washington, DC: Institute of Medicine; 2007.
11.
Brady  KT, Dansky  BS, Back  SE, Foa  EB, Carroll  KM.  Exposure therapy in the treatment of PTSD among cocaine-dependent individuals: preliminary findings.  J Subst Abuse Treat. 2001;21(1):47-54. doi:10.1016/S0740-5472(01)00182-9PubMedGoogle ScholarCrossref
12.
Coffey  SF, Dansky  BS, Brady  KT. Exposure-based, trauma-focused therapy for comorbid posttraumatic stress disorder-substance use disorder. In: Ouimette  P, Brown  PJ, eds.  Trauma and Substance Abuse: Causes, Consequences, and Treatment of Comorbid Disorders. Washington, DC: American Psychological Association; 2003:127-146. doi:10.1037/10460-007
13.
Riggs  DS, Foa  EB. Treatment for co-morbid posttraumatic stress disorder and substance use disorders. In:  Anxiety and Substance Use Disorders. New York, NY: Springer; 2008:119-137. doi:10.1007/978-0-387-74290-8_7
14.
Triffleman  E, Carroll  K, Kellogg  S.  Substance dependence posttraumatic stress disorder therapy: an integrated cognitive-behavioral approach.  J Subst Abuse Treat. 1999;17(1-2):3-14. doi:10.1016/S0740-5472(98)00067-1PubMedGoogle ScholarCrossref
15.
National Institute for Health and Clinical Practice.  Guideline for Post-traumatic Stress Disorder. Bethesda, MD: National Institute for Health and Clinical Practice; 2018.
16.
American Psychological Association Guideline Development Panel for the Treatment of PTSD in Adults.  Clinical Practice Guideline for the Treatment of Posttraumatic Stress Disorder (PTSD) in Adults. Washington, DC: American Psychological Association; 2017.
17.
National Institute of Health and Care Excellence (NICE).  Post-traumatic Stress Disorder: Management (Clinical Guideline). London, England: National Institute of Health Care and Excellence; 2005.
18.
Roberts  NP, Roberts  PA, Jones  N, Bisson  JI.  Psychological interventions for post-traumatic stress disorder and comorbid substance use disorder: a systematic review and meta-analysis.  Clin Psychol Rev. 2015;38:25-38. doi:10.1016/j.cpr.2015.02.007PubMedGoogle ScholarCrossref
19.
Mills  KL, Teesson  M, Back  SE,  et al.  Integrated exposure-based therapy for co-occurring posttraumatic stress disorder and substance dependence: a randomized controlled trial.  JAMA. 2012;308(7):690-699. doi:10.1001/jama.2012.9071PubMedGoogle ScholarCrossref
20.
Ruglass  LM, Lopez-Castro  T, Papini  S, Killeen  T, Back  SE, Hien  DA.  Concurrent treatment with prolonged exposure for co-occurring full or subthreshold posttraumatic stress disorder and substance use disorders: a randomized clinical trial.  Psychother Psychosom. 2017;86(3):150-161. doi:10.1159/000462977PubMedGoogle ScholarCrossref
21.
Persson  A, Back  SE, Killeen  TK,  et al.  Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE): a pilot study in alcohol-dependent women.  J Addict Med. 2017;11(2):119-125. doi:10.1097/ADM.0000000000000286PubMedGoogle ScholarCrossref
22.
Becker  CB, Zayfert  C, Anderson  E.  A survey of psychologists’ attitudes towards and utilization of exposure therapy for PTSD.  Behav Res Ther. 2004;42(3):277-292. doi:10.1016/S0005-7967(03)00138-4PubMedGoogle ScholarCrossref
23.
Brown  VB, Najavits  LM, Cadiz  S, Finkelstein  N, Heckman  JP, Rechberger  E; Seeking Safety Group.  Implementing an evidence-based practice.  J Psychoactive Drugs. 2007;39(3):231-240. doi:10.1080/02791072.2007.10400609PubMedGoogle ScholarCrossref
24.
Najavits  LM. Seeking safety. In: Follette  VM, Ruzek  JI, eds.  Cognitive-Behavioral Therapies for Trauma. New York, NY: Guildford Press; 2006.
25.
Back  SE, Foa  EB, Killeen  TK,  et al.  Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE): Therapist Guide. Oxford, England: Oxford University Press; 2014.
26.
Najavits  LM.  Seeking Safety: A Treatment Manual for PTSD and Substance Abuse. New York, NY: Guilford Press; 2002.
27.
Norman  SB, Haller  M, Spadoni  AD,  et al.  Maximizing the utility of a single site randomized controlled psychotherapy trial.  Contemp Clin Trials. 2015;42:244-251. doi:10.1016/j.cct.2015.04.011PubMedGoogle ScholarCrossref
28.
Franklin  CL, Raines  AM, Chambliss  JL, Walton  JL, Maieritsch  KP.  Examining various subthreshold definitions of PTSD using the Clinician Administered PTSD Scale for DSM-5.  J Affect Disord. 2018;234:256-260. doi:10.1016/j.jad.2018.03.001PubMedGoogle ScholarCrossref
29.
Weathers  FW, Bovin  MJ, Lee  DJ,  et al.  The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5): development and initial psychometric evaluation in military veterans.  Psychol Assess. 2018;30(3):383-395. doi:10.1037/pas0000486PubMedGoogle ScholarCrossref
30.
First  MB, Spitzer  RL, Gibbon  M, Williams  JB.  Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. Washington, DC: American Psychiatric Publishing; 2002.
31.
Sobell  LC, Sobell  MB. Timeline follow-back: a technique for assessing self reported alcohol consumption. In: Litten  R, Allen  JP, eds.  Measuring Alcohol Consumption: Psychological and Biochemical Methods. Clifton, NJ: Humana Press; 1992:41-72. doi:10.1007/978-1-4612-0357-5_3
32.
SAS Institute.  SAS/IML Studio 3. 3 for SAS/STAT Users. Cary, NY: SAS Institute; 2010.
33.
McHugh  ML.  Interrater reliability: the kappa statistic.  Biochem Med (Zagreb). 2012;22(3):276-282. doi:10.11613/BM.2012.031PubMedGoogle ScholarCrossref
34.
Sobell  LC, Brown  J, Leo  GI, Sobell  MB.  The reliability of the Alcohol Timeline Followback when administered by telephone and by computer.  Drug Alcohol Depend. 1996;42(1):49-54. doi:10.1016/0376-8716(96)01263-XPubMedGoogle ScholarCrossref
35.
Paterson  DL, Swindells  S, Mohr  J,  et al.  Adherence to protease inhibitor therapy and outcomes in patients with HIV infection.  Ann Intern Med. 2000;133(1):21-30. doi:10.7326/0003-4819-133-1-200007040-00004PubMedGoogle ScholarCrossref
36.
Attkisson  CC, Zwick  R.  The client satisfaction questionnaire: psychometric properties and correlations with service utilization and psychotherapy outcome.  Eval Program Plann. 1982;5(3):233-237. doi:10.1016/0149-7189(82)90074-XPubMedGoogle ScholarCrossref
37.
Hien  DA, Jiang  H, Campbell  ANC,  et al.  Do treatment improvements in PTSD severity affect substance use outcomes? a secondary analysis from a randomized clinical trial in NIDA’s Clinical Trials Network.  Am J Psychiatry. 2010;167(1):95-101. doi:10.1176/appi.ajp.2009.09091261PubMedGoogle ScholarCrossref
38.
Najavits  L, Liese  B.  Seeking Safety Adherence Scale. Version 3. Boston, MA: Harvard Medical School/McLean Hospital; 2003.
39.
Haller  M, Norman  SB, Cummins  K,  et al.  Integrated cognitive behavioral therapy versus cognitive processing therapy for adults with depression, substance use disorder, and trauma.  J Subst Abuse Treat. 2016;62:38-48. doi:10.1016/j.jsat.2015.11.005PubMedGoogle ScholarCrossref
40.
IBM.  IBM SPSS statistics version 21. Boston, MA: International Business Machines Corp; 2012:126.
41.
Hien  DA, Smith  KZ, Owens  M, López-Castro  T, Ruglass  LM, Papini  S.  Lagged effects of substance use on PTSD severity in a randomized controlled trial with modified prolonged exposure and relapse prevention.  J Consult Clin Psychol. 2018;86(10):810-819. doi:10.1037/ccp0000345PubMedGoogle ScholarCrossref
42.
Back  SE, Brady  KT, Jaanimägi  U, Jackson  JL.  Cocaine dependence and PTSD: a pilot study of symptom interplay and treatment preferences.  Addict Behav. 2006;31(2):351-354. doi:10.1016/j.addbeh.2005.05.008PubMedGoogle ScholarCrossref
43.
Read  JP, Brown  PJ, Kahler  CW.  Substance use and posttraumatic stress disorders: symptom interplay and effects on outcome.  Addict Behav. 2004;29(8):1665-1672. doi:10.1016/j.addbeh.2004.02.061PubMedGoogle ScholarCrossref
44.
Myrick  H, Brady  K.  Current review of the comorbidity of affective, anxiety, and substance use disorders.  Curr Opin Psychiatry. 2003;16(3):261-270. doi:10.1097/01.yco.0000069080.26384.d8Google Scholar
45.
Sharkansky  EJ, Brief  DJ, Peirce  JM, Meehan  JC, Mannix  LM.  Substance abuse patients with posttraumatic stress disorder (PTSD): identifying specific triggers of substance use and their associations with PTSD symptoms.  Psychol Addict Behav. 1999;13(2):89-97. doi:10.1037/0893-164X.13.2.89Google ScholarCrossref
46.
Dansky  BS, Brady  KT, Saladin  ME.  Untreated symptoms of PTSD among cocaine-dependent individuals: changes over time.  J Subst Abuse Treat. 1998;15(6):499-504. doi:10.1016/S0740-5472(97)00293-6PubMedGoogle ScholarCrossref
47.
van Minnen  A, Harned  MS, Zoellner  L, Mills  K.  Examining potential contraindications for prolonged exposure therapy for PTSD.  Eur J Psychotraumatol. 2012;3(1):18805. doi:10.3402/ejpt.v3i0.18805PubMedGoogle ScholarCrossref
48.
Najavits  LM, Hamilton  N, Miller  N, Griffin  J, Welsh  T, Vargo  M.  Peer-led seeking safety: results of a pilot outcome study with relevance to public health.  J Psychoactive Drugs. 2014;46(4):295-302. doi:10.1080/02791072.2014.922227PubMedGoogle ScholarCrossref
49.
Kaysen  D, Schumm  J, Pedersen  ER, Seim  RW, Bedard-Gilligan  M, Chard  K.  Cognitive processing therapy for veterans with comorbid PTSD and alcohol use disorders.  Addict Behav. 2014;39(2):420-427. doi:10.1016/j.addbeh.2013.08.016PubMedGoogle ScholarCrossref
50.
Perez-Dandieu  B, Tapia  G.  Treating trauma in addiction with EMDR: a pilot study.  J Psychoactive Drugs. 2014;46(4):303-309. doi:10.1080/02791072.2014.921744PubMedGoogle ScholarCrossref
51.
Sloan  DM, Feinstein  BA, Gallagher  MW, Beck  JG, Keane  TM.  Efficacy of group treatment for posttraumatic stress disorder symptoms: a meta-analysis.  Psychol Trauma. 2013;5(2):176-183. doi:10.1037/a0026291Google ScholarCrossref
52.
Resick  PA, Wachen  JS, Dondanville  KA,  et al; and the STRONG STAR Consortium.  Effect of group vs individual cognitive processing therapy in active-duty military seeking treatment for posttraumatic stress disorder: a randomized clinical trial.  JAMA Psychiatry. 2017;74(1):28-36. doi:10.1001/jamapsychiatry.2016.2729PubMedGoogle ScholarCrossref
53.
Watts  BV, Schnurr  PP, Mayo  L, Young-Xu  Y, Weeks  WB, Friedman  MJ.  Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.  J Clin Psychiatry. 2013;74(6):e541-e550. doi:10.4088/JCP.12r08225PubMedGoogle ScholarCrossref
54.
Back  SE, Killeen  T, Badour  CL,  et al.  Concurrent treatment of substance use disorders and PTSD using prolonged exposure: a randomized clinical trial in military veterans.  Addict Behav. 2019;90:369-377. doi:10.1016/j.addbeh.2018.11.032PubMedGoogle ScholarCrossref
Original Investigation
April 24, 2019

Efficacy of Integrated Exposure Therapy vs Integrated Coping Skills Therapy for Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: A Randomized Clinical Trial

Author Affiliations
  • 1VA San Diego Healthcare System, San Diego, California
  • 2National Center for PTSD, White River Junction, Vermont
  • 3VA Center of Excellence for Stress and Mental Health, San Diego, California
  • 4Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla
  • 5James A. Haley Veterans’ Hospital, Tampa, Florida
  • 6Ralph H. Johnson VA Medical Center, Charleston, South Carolina
  • 7San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego
  • 8Department of Psychology, University of Texas, Austin
JAMA Psychiatry. 2019;76(8):791-799. doi:10.1001/jamapsychiatry.2019.0638
Key Points

Question  Is integrated prolonged exposure therapy tolerable and more efficacious than present-centered integrated coping skills therapy for reducing posttraumatic stress disorder symptoms and alcohol use in patients with comorbid posttraumatic stress disorder and alcohol use disorder?

Findings  In this randomized clinical trial of 119 patients, exposure therapy reduced posttraumatic stress disorder symptoms significantly more than coping skills therapy after treatment and at 3- and 6-month follow-ups. Participants in both treatment arms had reductions in heavy drinking days over time.

Meaning  Integrated prolonged exposure therapy was well tolerated and had greater efficacy for reducing posttraumatic stress disorder symptoms than present-centered integrated coping skills therapy.

Abstract

Importance  Co-occurrence of posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) is common and associated with psychiatric and functional problems. Understanding whether exposure therapy is tolerable and efficacious for treating PTSD and AUD is critical to ensure that best practice treatments are available.

Objective  To compare the efficacy of integrated (ie, targeting both PTSD and alcohol use) prolonged exposure (I-PE) therapy with present-centered integrated coping skills (I-CS) therapy, a more commonly available treatment, in reducing PTSD symptoms and alcohol use.

Design, Setting, and Participants  This prospective randomized clinical trial with masked assessments considered 186 veterans seeking Veterans Affairs mental health services. A total of 119 veterans with PTSD and AUD were randomized. Data were collected from February 1, 2013, to May 31, 2017, before treatment, after treatment, and at 3- and 6-month follow-ups. Intention-to-treat analyses were performed.

Interventions  Veterans underwent I-PE (Concurrent Treatment of PTSD and Substance Use Disorder Using Prolonged Exposure) or I-CS (Seeking Safety) therapy.

Main Outcomes and Measures  A priori planned outcomes were PTSD symptoms (Clinician Administered PTSD Scale for DSM-5) and percentage of heavy drinking days (Timeline Follow-Back) before treatment, after treatment, and at 3- and 6-month follow-ups.

Results  A total of 119 veterans (mean [SD] age, 41.6 [12.6] years; 107 [89.9%] male) were randomized. Linear mixture models found that PTSD symptoms decreased in both conditions, with a significantly greater decrease for I-PE treatment compared with I-CS treatment (treatment × time interaction, −2.83; F3,233.1 = 4.92; Cohen d = 0.41; P = .002). The percentage of heavy drinking days improved in both conditions but was not statistically different between I-PE and I-CS treatment (treatment × time interaction, 1.8%; F3,209.9 = 0.18; Cohen d = 0.04; P = .91).

Conclusions and Relevance  The I-PE arm had a greater reduction in PTSD symptoms than the I-CS arm and comparable drinking decreases. The study provides evidence that exposure therapy is more efficacious in treating PTSD than a more commonly available integrated treatment without exposure for comorbid PTSD and AUD.

Trial Registration  ClinicalTrials.gov identifier: NCT01601067

Introduction

Posttraumatic stress disorder (PTSD) frequently co-occurs with alcohol use disorders (AUDs) in the general population1 and among veterans.2 Individuals with PTSD and AUD exhibit briefer abstinence periods, greater risk of suicidality and homelessness, and more medical, legal, and psychosocial problems than individuals with either disorder alone.3-7

Trauma-focused exposure psychotherapies, such as prolonged exposure therapy,8 are the first line of treatment of PTSD based on numerous studies and clinical practice guidelines.9-17 Several studies18-21 have found that, for patients with PTSD and AUD or PTSD comorbid with alcohol and/or other substance use disorders (A/SUDs), exposure therapy is more efficacious in reducing PTSD symptoms than A/SUD-only treatment. However, individuals with PTSD and AUD are often not offered exposure therapy because of concerns that exposure to trauma memories may lead to increased drinking and crises.22 Furthermore, treatment attendance is sometimes lower with exposure therapy than in A/SUD-only treatment.18 Psychotherapy for PTSD and AUD that focuses on improving coping skills is well accepted and highly disseminated.23 Such therapy posits that establishing safety through better coping is the first priority for patients with PTSD and A/SUD and that eliciting trauma memories too early in treatment may be harmful.24 Although session attendance is comparable to A/SUD-only treatment, questions remain about whether coping skills therapy is more efficacious than A/SUD-only care.18 To date, no randomized clinical trials (RCTs) have directly compared the efficacy and tolerability of 2 active integrated PTSD and AUD interventions, specifically, exposure and coping skills therapies. In addition, many studies of PTSD and AUD treatment have been limited by narrow inclusion and exclusion criteria and methodologic problems, such as low recruitment, leading to risk of bias and low power to detect differences among treatments.18 Understanding which interventions are the most efficacious and tolerable for treating PTSD and AUD and, in particular, whether exposure therapy is tolerable and more efficacious than coping skills therapy even when AUD is present is critical to improving outcomes and ensuring best practice treatments are available to patients with comorbid conditions.

The current trial was designed to address these critical gaps. The objective was to compare integrated prolonged exposure (I-PE) therapy, using the Concurrent Treatment for PTSD and Substance Use Disorder Using Prolonged Exposure (COPE)25 protocol, with the most widely used18 integrated coping skills (I-CS) therapy, Seeking Safety (SS).26 We hypothesized that I-PE treatment would produce greater reductions in PTSD symptoms after treatment and at follow-ups and that both arms would have reductions in the percentage of heavy drinking days (PHDD) after treatment but that the I-PE therapy arm would have a significantly lower PHDD at 3- and 6-month follow-ups. The PHDD variable was selected as the primary alcohol use outcome because many participants chose harm reduction rather than abstinence as their treatment goal. In addition to the primary outcomes of PTSD symptoms and PHDD, we examined the percentage of days abstinent (PDA) from alcohol and PTSD remission at each time point. Discontinuations attributable to serious adverse events and treatment satisfaction were examined as markers of tolerability and satisfaction.

Methods
Design

The study was an RCT of 2 active treatments, I-PE and I-CS therapy, for PTSD and AUD. Participants gave written informed consent before enrollment by the study coordinator (E.B.). Independent evaluators were masked to treatment assignment for study duration. Details of methods are published elsewhere.27 The study was approved by the VA San Diego Research Review Board. The trial protocol can be found in the Supplement 1.

Participants

Demographic characteristics are given in Table 1. Participants were 119 adult veterans (107 male) seeking treatment at a large urban veterans affairs (VA) facility. Patients who potentially had PTSD and AUD based on medical record review were referred to the study by mental health practitioners. Patients also responded to flyers posted around the VA facility. Eligible participants had current full or subthreshold PTSD (up to 1 symptom missing)28 and current AUD with at least 20 days of heavy alcohol use in the past 90 days not in a restricted environment and wanted to reduce or abstain from alcohol use. Exclusion criteria were acute suicidality, unmanaged psychosis or mania, and intravenous drug use. Participants were asked not to engage in other PTSD psychotherapy during study treatment. Participation in other mental health treatment (medications and psychotherapy) was tracked.

Procedures

Recruitment took place from February 1, 2013, to May 31, 2017. After a telephone screen, participants were scheduled to provide written informed consent and complete baseline assessments. The Clinician Administered PTSD Scale for DSM-5 (CAPS-5),29 the Structured Clinical Interview for DSM-IV-TR (SCID-IV) Module E,30 and the Timeline Follow-Back31 confirmed study criteria for PTSD, AUD, and alcohol use, respectively. Participants then met with a study practitioner (M.H., B.C.D., U.S.M., P.J.C., T.M, and others) to learn more about both therapies and ask any remaining questions about the treatment process. Balanced block randomization (variable blocks of 8-12 individuals) with masked allocation was stratified by sex. A statistician not otherwise involved in the study used SAS Institute’s32 random number generator for randomization. Participants were informed of their treatment condition at their first therapy session. Participants engaged in 12 to 16 sessions of psychotherapy and then completed measures after treatment and at 3- and 6-month posttreatment follow-ups. Compensation was $20 at baseline, $30 after treatment, and $50 per follow-up.

Masked independent evaluators completed training and achieved at least 90% agreement on CAPS-5 item scores before conducting assessments. Interrater reliability, conducted on 11% of randomly selected CAPS-5 assessments, was excellent (κ = 0.94 for diagnosis; intraclass correlation coefficient, 0.99; 95% CI, 0.98-0.99).29,33 Study therapists were 13 licensed psychologists, postdoctoral fellows, clinical psychology interns, and doctoral students. Most participants were seen by therapists who administered both treatments (to control for therapist effects). The exception was doctoral students, who were only able to see 1 to 3 participants during their training rotation (a parallel set of analyses were conducted that excluded 11 participants treated by doctoral students to ensure robustness of the findings). Therapists received training in study protocols through didactics, videos, and practice sessions with a supervisor before treating a participant. The first time that therapists administered each intervention, all sessions were rated for fidelity. Henceforth, all sessions were recorded and 10% were rated. Therapists received weekly individual and group supervision.

Measures

The CAPS-5 (score range, 0-80, with 0 indicating no PTSD symptoms and 80 indicating extreme ratings across all symptoms), a 30-item structured interview29 considered to be the criterion standard for PTSD, was the primary measure of PTSD symptoms and diagnosis. Diagnosis was determined using the rule of a severity score of 2 or higher, which follows DSM-5 PTSD criteria. A CAPS-5 diagnosis using this rule displayed strong interrater reliability (κ = 0.78), and severity scores had strong internal consistency (α = .88) in the development sample.29 Internal consistency in the current sample was strong (α = .83). At each time point, PTSD remission was defined as a total score less than 12 because it is not possible to have a diagnosis of PTSD with a score less than 12. This optimally conservative cut-off was recommended by CAPS developers (P. P. Schnurr, PhD, and B. P. Marx, PhD, written communication, April 2018).

Frequency and quantity of alcohol use were assessed using the Timeline Follow-Back, a calendar-assisted structured clinical interview31 that displays good psychometric properties.34 The PHDD was calculated by dividing the number of days in which 5 or more drinks for men or 4 or more drinks for women were consumed by the total number of days in the reference period. Toxicology screens were completed during a randomly selected week each month, and Breathalyzer tests were administered if there was indication that a participant came to an appointment after consuming alcohol.

The Modified Interview of Antiretroviral Medication Use35 was used to assess past week adherence to psychotropic medications. The Client Satisfaction Questionnaire (score range, 8-32, with 8 indicating extremely poor satisfaction and 32 indicating extremely high satisfaction), a widely used measure of psychotherapy satisfaction,36 was administered every other therapy session. The mean across-treatment sessions were computed to ascertain satisfaction.

Treatments

The I-PE and I-CS treatments were delivered in 90-minute individual sessions. Therapy was 12 sessions, with the option of completing up to 16 sessions if the participant and therapist agreed that treatment goals were not yet met. Participants were encouraged to attend therapy 1 to 2 times per week on consecutive weeks but allowed up to 6 months to finish treatment.

COPE25 is an integrated PTSD and SUD treatment that augments prolonged exposure with cognitive behavioral relapse prevention skills for SUD in each session. COPE includes in vivo exposures to trauma reminders (starting in session 3) and repeated imaginal exposures to the trauma memory (starting in session 4). The COPE manual includes 12 sessions. For participants who completed 13 to 16 sessions, up to 4 SUD skills were repeated (S. E. Back, PhD, oral communication, November 2012).

The SS treatment26 is a present-focused, PTSD and SUD integrated therapy that teaches cognitive behavioral and interpersonal techniques and case management. It consists of 24 modules. Each module includes safe coping skills. Trauma is discussed in the context of how it is currently affecting the patient’s life. For this study, session topics were predetermined for sessions 1 through 12 based on previous research.37 Participants completing 13 to 16 sessions selected from the remaining topics.

Forty-seven I-PE and 59 I-CS therapy session recordings were rated for fidelity. A score of 2 or higher (range, 0-4, with 0 indicating no fidelity and 4 indicating excellent fidelity) on the COPE fidelity scale indicated adequate adherence and competence with I-PE therapy.11,20 Strong adherence (mean [SD], 3.18 [0.48]) and competency were maintained (mean [SD], 3.65 [0.42]). The SS adherence scale,38 a 4-point scale (range, 0-3, with 0 indicating not done or harmful and 3 indicating done thoroughly or extremely helpful), was used for I-CS therapy. Strong adherence (mean [SD], 2.45 [0.27]) and competency (mean [SD], 2.59 [0.26]) were maintained.

Statistical Analysis

Sample size was determined to ensure adequate statistical power to detect between-group differences in PTSD and alcohol use after treatment. We anticipated a large between-group effect size for PTSD based on findings of studies evaluating I-PE and I-CS treatment for PTSD18; thus, the sample size was based on alcohol use. We estimated the between-group standardized effect for alcohol use to be 0.58 based on an earlier trial conducted by our team.39 Ninety-six participants (48 in each condition) were needed to have 80% power with a 2-tailed test with α at .05 to detect this estimated effect size using intention to treat. The final sample size of 119 exceeded the target by 24%.

Linear mixed models were used to analyze the continuous outcomes (CAPS, PHDD, and PDA) using SPSS, version 21 (SPSS).40 These models allow for an intention-to-treat analysis in which all available data from randomized participants are included to estimate unbiased variable estimates under the missing at random assumption. Treatment condition, time, and their interaction were treated as fixed effects, and the intercept was specified as a random effect to account for the repeated observations within participants. Analyses were conducted using an identity covariance matrix for the random effects and an autoregressive covariance for the repeated effect of time. Between-group effect sizes were computed according to Cohen d using estimated data from these procedures. Rates of PTSD remission (CAPS score <12) were compared for participants for whom data were available at each time point using χ2 tests. A 1-sided P < .05 was considered to be statistically significant.

Results

A total of 119 veterans (mean [SD] age, 41.6 [12.6] years; 107 [89.9%] male) were randomized. Figure 1 shows the flow of the patients through the study. The I-PE and I-CS arms did not significantly differ on background variables or on baseline measures of the primary outcomes (Table 1). The I-PE arm had higher rates than the I-CS arm of taking psychotropic medication (77.8% vs 51.8%; t117 = 3.07; P = .003). Number of sessions completed was higher in the I-CS arm than the I-PE arm (11.4 vs 8.4; t117 = 3.47; P = .001). Session attendance was comparable between the 2 treatments through session 5, but the proportion attending I-PE treatment was lower than the proportion attending I-CS treatment at subsequent sessions.

The estimated marginal means from the mixed models for outcomes over time are given in Table 2. The CAPS scores decreased in both arms, with a significantly greater decrease in CAPS scores for the I-PE arm compared with the I-CS arm (treatment × time interaction, −2.83; F3,233.1 = 4.92; Cohen d = 0.41; P = .002) (Figure 2). The PHDD decreased in both arms, but these changes were not statistically different between arms (treatment × time interaction, 1.8%; F3,209.9 = 0.18; Cohen d = 0.04; P = .91). The PDA had the same pattern of results as the PHDD.

The I-PE arm had significantly higher rates of PTSD remission than the I-CS arm after treatment (8 of 36 [22.2%] vs 3 of 44 [6.8%]; χ2 = 3.96; P = .047) and 3-month follow-up (10 of 40 [25%] vs 2 of 33 [6.1%]; χ2 = 4.72; P = .03); there was a marginal group difference in favor of I-PE treatment at 6-month follow-up (10 of 30 [33.3%] vs 5 of 34 [14.7%]; χ2 = 3.08; P = .08) (Figure 3).

No participants were discharged from the study because of serious adverse events. Satisfaction in I-PE (mean [SD], 28.9 [2.7]) and I-CS (mean [SD], 29.4 [2.8]) treatment was high and did not differ between arms. A parallel set of analyses that excluded the 11 participants seen by doctoral students found no meaningful differences from the estimates using the full sample.

Discussion

The aim of this study was to compare the relative efficacy of 2 promising psychotherapies for PTSD and AUD. The 2 treatments are based on vastly different models. Whereas I-PE treatment posits that exposure to trauma-related memories and emotions is critical, I-CS treatment posits that patients with PTSD and AUD may not be ready for exposure and that a focus on better coping is key to recovery. As hypothesized, participants in both conditions had significant reductions in PTSD symptoms with greater reductions in the I-PE arm over time. The PTSD remission rates were greater for the I-PE arm than the I-CS arm.

Contrary to our hypotheses, no statistically significant differences were found between conditions in alcohol use at follow-ups. This hypothesis was based on research suggesting that as PTSD resolves, individuals are more successful in reducing drinking.37,41-46 Our last follow-up was 6 months after treatment. It is possible that the effect we hypothesized would be seen further downstream. However, PTSD symptoms improved in both conditions, and participants in both conditions received cognitive behavioral interventions for AUD. Although I-PE and I-CS treatments differ greatly in how PTSD is treated, the cognitive behavioral AUD components may have been too similar for one condition to outperform the other.

Key implications of this novel direct comparison of 2 active integrated PTSD and AUD treatments are that patients with PTSD and AUD can tolerate and benefit from exposure therapy and, regarding PTSD, exposure therapy is more efficacious than therapy without exposure. This information is critical because having an AUD continues to be a barrier to receiving exposure therapy because of therapist perceptions of patients’ fragility (ie, beliefs that patients will not be able to handle trauma-related memories and may have an increase in alcohol use).47 Participants were not required to be abstinent and were not excluded for having additional SUDs (except intravenous drug use), and the mean number of trauma types experienced was more than 7, further reinforcing that patients with complicated, comorbid conditions can tolerate and benefit from exposure therapy.

Although I-PE treatment produced greater PTSD symptom reduction and remission rates, both treatments produced decreases in PTSD symptoms, reductions in alcohol use, and high treatment satisfaction. These findings raise questions regarding which treatment should be offered to whom and when. Findings of this study and a meta-analysis18 that found I-PE treatment to be more efficacious than AUD-only treatment suggest that I-PE treatment should be offered when possible. The I-CS treatment may be useful when exposure therapy is refused by a patient or is not available. The I-CS treatment may be less costly to implement in that it can be delivered in groups, in 45- to 60-minute sessions,26 and by trained peers.48 However, in the present study, therapists were doctoral psychology trainees and psychologists and sessions were individual and 90 minutes long. Results may not generalize to delivery using a group format or shorter sessions. Given the better PTSD outcomes with fewer sessions attended, I-PE treatment may ultimately be more cost effective. Future research is needed to investigate the cost effectiveness of I-PE treatment compared with I-CS treatment.

It is not clear whether some participants in the I-PE arm attended fewer sessions because they found I-PE treatment to be too difficult, if they completed treatment more quickly because they felt better, or for other reasons. Prolonged exposure is generally conducted in approximately 12 sessions.8 The mechanism of exposure (processing trauma-related distress, overcoming avoidance of trauma reminders, and challenging beliefs that one cannot handle trauma memories and reminders through exposure) may work more quickly and effectively than learning to cope better with current life difficulties. Future research is needed to understand why participants had better PTSD outcomes with I-PE treatment even though they attended significantly fewer sessions, and who is most likely to benefit from each treatment under which conditions.

To our knowledge, there has been little research on treating comorbid PTSD and A/SUD with trauma-focused treatments other than exposure. Preliminary studies suggest that cognitive processing therapy49 and eye movement desensitization and reprocessing50 are promising. Randomized clinical trials with these psychotherapies would further expand treatment options for PTSD and A/SUD.

Strengths and Limitations

This study has several strengths. It is the first RCT of which we are aware to compare 2 active PTSD and AUD psychotherapies. Many previous treatment studies of PTSD and AUD have had underrecruitment and limitations associated with risk of bias.18 The study used a rigorous methodologic design and was powered to evaluate hypotheses. The study had minimal exclusion criteria, allowing for evaluation of a clinically complex, real-world comorbid population.

A limitation is that delivery of I-CS treatment in this study was different from how the SS treatment is typically delivered (in group or shorter individual sessions).18,26 We chose to deliver 90-minute individual sessions to match for dose (COPE uses 90-minute individual sessions) rather than have participants in the I-PE arm receive 30 to 45 minutes more of therapy per session. The trade-off of this choice is that findings regarding I-CS treatment may not generalize to other, more standard delivery formats. In general, group treatments for PTSD have lower effect sizes than individual treatments51-53; thus, current findings may not generalize to I-CS treatment delivered in group format. Other limitations of the study included a mostly male veteran sample, potentially limiting generalizability. Attrition was high (73.9% completed at least 1 posttreatment assessment), although comparable with other RCTs of I-PE treatment (eg, 48%-79% completing at least 1 posttreatment assessment).19,20,54 Consistent with other studies of PTSD and AUD,18 the exposure therapy condition had fewer sessions attended and higher study dropout.

Conclusions

This study provides evidence that exposure therapy is more efficacious in treating PTSD among individuals with PTSD and AUD than a more commonly available integrated treatment without exposure. Exposure therapy did not worsen drinking outcomes, and both I-PE and I-CS treatment reduced heavy drinking.

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Article Information

Accepted for Publication: March 29, 2019.

Corresponding Author: Sonya Norman, PhD, VA San Diego Healthcare System, 3350 La Jolla Village Dr, MC116B, San Diego, CA 92161 (snorman@ucsd.edu).

Published Online: April 24, 2019. doi:10.1001/jamapsychiatry.2019.0638

Author Contributions: Drs S.B. Norman and Trim had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: S.B. Norman, Trim, Davis, Colvonen, Mayes.

Acquisition, analysis, or interpretation of data: S.B. Norman, Trim, Haller, Myers, Colvonen, Blanes, Lyons, Siegel, Angkaw, G.J. Norman.

Drafting of the manuscript: S.B. Norman, Trim, Haller, Myers, Colvonen, Blanes, Lyons, G.J. Norman.

Critical revision of the manuscript for important intellectual content: Trim, Haller, Davis, Myers, Colvonen, Lyons, Siegel, Angkaw, G.J. Norman, Mayes.

Statistical analysis: Trim, Haller, Colvonen, Lyons, G.J. Norman.

Obtained funding: S.B. Norman, Myers.

Administrative, technical, or material support: Myers, Colvonen, Blanes, Lyons, Siegel.

Supervision: S.B. Norman, Trim, Colvonen, Angkaw, Mayes.

Conflict of Interest Disclosures: Drs S.B. Norman, Trim, Haller, Davis, Colvonen, Angkaw, and Mayes, Ms Siegel, and Ms Blanes reported receiving funding from the US Department of Veterans Affairs during the conduct of this study. Dr Myers and Mr Lyons reported receiving funding from the National Institute on Alcohol Abuse and Alcoholism during the conduct of this study. No other disclosures were reported.

Funding/Support: This study was supported by VA Clinical Science Research and Development Merit Grant 1I01CX000756 (Dr S. Norman, principal investigator). Other funding support included training fellowships through the VA Office of Academic Affiliation (Drs Haller and Colvonen) and T32 fellowship T32AA013525 through the National Institute on Alcohol Abuse and Alcoholism (Dr Myers and Mr Lyons).

Role of the Funder/Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication.

Data Sharing Statement: See Supplement 2.

Additional Contributions: Paula Schnurr, PhD, and Jessica Hamblen, PhD, National Center for PTSD, White River Junction, Vermont, and Dartmouth College, Hanover, New Hampshire, provided consultation regarding study design and implementation. They were not compensated for their work. We thank the therapists and research assistants involved in the study.

References
1.
Kessler  RC, Chiu  WT, Demler  O, Merikangas  KR, Walters  EE.  Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.  Arch Gen Psychiatry. 2005;62(6):617-627. doi:10.1001/archpsyc.62.6.617PubMedGoogle ScholarCrossref
2.
Seal  KH, Cohen  G, Waldrop  A, Cohen  BE, Maguen  S, Ren  L.  Substance use disorders in Iraq and Afghanistan veterans in VA healthcare, 2001-2010: implications for screening, diagnosis and treatment.  Drug Alcohol Depend. 2011;116(1-3):93-101. doi:10.1016/j.drugalcdep.2010.11.027PubMedGoogle ScholarCrossref
3.
Driessen  M, Schulte  S, Luedecke  C,  et al; TRAUMAB-Study Group.  Trauma and PTSD in patients with alcohol, drug, or dual dependence: a multi-center study.  Alcohol Clin Exp Res. 2008;32(3):481-488. doi:10.1111/j.1530-0277.2007.00591.xPubMedGoogle ScholarCrossref
4.
Tate  SR, Norman  SB, McQuaid  JR, Brown  SA.  Health problems of substance-dependent veterans with and those without trauma history.  J Subst Abuse Treat. 2007;33(1):25-32. doi:10.1016/j.jsat.2006.11.006PubMedGoogle ScholarCrossref
5.
Calabrese  JR, Prescott  M, Tamburrino  M,  et al.  PTSD comorbidity and suicidal ideation associated with PTSD within the Ohio Army National Guard.  J Clin Psychiatry. 2011;72(8):1072-1078. doi:10.4088/JCP.11m06956PubMedGoogle ScholarCrossref
6.
Edens  EL, Kasprow  W, Tsai  J, Rosenheck  RA.  Association of substance use and VA service-connected disability benefits with risk of homelessness among veterans.  Am J Addict. 2011;20(5):412-419. doi:10.1111/j.1521-0391.2011.00166.xPubMedGoogle ScholarCrossref
7.
Straus  E, Norman  SB, Haller  M, Southwick  SM, Hamblen  JL, Pietrzak  RH.  Differences in protective factors among U.S. Veterans with posttraumatic stress disorder, alcohol use disorder, and their comorbidity: results from the National Health and Resilience in Veterans Study.  Drug Alcohol Depend. 2019;194:6-12. doi:10.1016/j.drugalcdep.2018.09.011PubMedGoogle ScholarCrossref
8.
Foa  E, Hembree  E, Rothbaum  BO.  Prolonged Exposure Therapy for PTSD: Emotional Processing of Traumatic Experiences Therapist Guide. New York, NY: Oxford University Press; 2007. doi:10.1093/med:psych/9780195308501.001.0001
9.
Foa  EB, Dancu  CV, Hembree  EA, Jaycox  LH, Meadows  EA, Street  GP.  A comparison of exposure therapy, stress inoculation training, and their combination for reducing posttraumatic stress disorder in female assault victims.  J Consult Clin Psychol. 1999;67(2):194-200. doi:10.1037/0022-006X.67.2.194PubMedGoogle ScholarCrossref
10.
Institute of Medicine.  Treatment of Posttraumatic Stress Disorder: An Assessment of the Evidence. Washington, DC: Institute of Medicine; 2007.
11.
Brady  KT, Dansky  BS, Back  SE, Foa  EB, Carroll  KM.  Exposure therapy in the treatment of PTSD among cocaine-dependent individuals: preliminary findings.  J Subst Abuse Treat. 2001;21(1):47-54. doi:10.1016/S0740-5472(01)00182-9PubMedGoogle ScholarCrossref
12.
Coffey  SF, Dansky  BS, Brady  KT. Exposure-based, trauma-focused therapy for comorbid posttraumatic stress disorder-substance use disorder. In: Ouimette  P, Brown  PJ, eds.  Trauma and Substance Abuse: Causes, Consequences, and Treatment of Comorbid Disorders. Washington, DC: American Psychological Association; 2003:127-146. doi:10.1037/10460-007
13.
Riggs  DS, Foa  EB. Treatment for co-morbid posttraumatic stress disorder and substance use disorders. In:  Anxiety and Substance Use Disorders. New York, NY: Springer; 2008:119-137. doi:10.1007/978-0-387-74290-8_7
14.
Triffleman  E, Carroll  K, Kellogg  S.  Substance dependence posttraumatic stress disorder therapy: an integrated cognitive-behavioral approach.  J Subst Abuse Treat. 1999;17(1-2):3-14. doi:10.1016/S0740-5472(98)00067-1PubMedGoogle ScholarCrossref
15.
National Institute for Health and Clinical Practice.  Guideline for Post-traumatic Stress Disorder. Bethesda, MD: National Institute for Health and Clinical Practice; 2018.
16.
American Psychological Association Guideline Development Panel for the Treatment of PTSD in Adults.  Clinical Practice Guideline for the Treatment of Posttraumatic Stress Disorder (PTSD) in Adults. Washington, DC: American Psychological Association; 2017.
17.
National Institute of Health and Care Excellence (NICE).  Post-traumatic Stress Disorder: Management (Clinical Guideline). London, England: National Institute of Health Care and Excellence; 2005.
18.
Roberts  NP, Roberts  PA, Jones  N, Bisson  JI.  Psychological interventions for post-traumatic stress disorder and comorbid substance use disorder: a systematic review and meta-analysis.  Clin Psychol Rev. 2015;38:25-38. doi:10.1016/j.cpr.2015.02.007PubMedGoogle ScholarCrossref
19.
Mills  KL, Teesson  M, Back  SE,  et al.  Integrated exposure-based therapy for co-occurring posttraumatic stress disorder and substance dependence: a randomized controlled trial.  JAMA. 2012;308(7):690-699. doi:10.1001/jama.2012.9071PubMedGoogle ScholarCrossref
20.
Ruglass  LM, Lopez-Castro  T, Papini  S, Killeen  T, Back  SE, Hien  DA.  Concurrent treatment with prolonged exposure for co-occurring full or subthreshold posttraumatic stress disorder and substance use disorders: a randomized clinical trial.  Psychother Psychosom. 2017;86(3):150-161. doi:10.1159/000462977PubMedGoogle ScholarCrossref
21.
Persson  A, Back  SE, Killeen  TK,  et al.  Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE): a pilot study in alcohol-dependent women.  J Addict Med. 2017;11(2):119-125. doi:10.1097/ADM.0000000000000286PubMedGoogle ScholarCrossref
22.
Becker  CB, Zayfert  C, Anderson  E.  A survey of psychologists’ attitudes towards and utilization of exposure therapy for PTSD.  Behav Res Ther. 2004;42(3):277-292. doi:10.1016/S0005-7967(03)00138-4PubMedGoogle ScholarCrossref
23.
Brown  VB, Najavits  LM, Cadiz  S, Finkelstein  N, Heckman  JP, Rechberger  E; Seeking Safety Group.  Implementing an evidence-based practice.  J Psychoactive Drugs. 2007;39(3):231-240. doi:10.1080/02791072.2007.10400609PubMedGoogle ScholarCrossref
24.
Najavits  LM. Seeking safety. In: Follette  VM, Ruzek  JI, eds.  Cognitive-Behavioral Therapies for Trauma. New York, NY: Guildford Press; 2006.
25.
Back  SE, Foa  EB, Killeen  TK,  et al.  Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE): Therapist Guide. Oxford, England: Oxford University Press; 2014.
26.
Najavits  LM.  Seeking Safety: A Treatment Manual for PTSD and Substance Abuse. New York, NY: Guilford Press; 2002.
27.
Norman  SB, Haller  M, Spadoni  AD,  et al.  Maximizing the utility of a single site randomized controlled psychotherapy trial.  Contemp Clin Trials. 2015;42:244-251. doi:10.1016/j.cct.2015.04.011PubMedGoogle ScholarCrossref
28.
Franklin  CL, Raines  AM, Chambliss  JL, Walton  JL, Maieritsch  KP.  Examining various subthreshold definitions of PTSD using the Clinician Administered PTSD Scale for DSM-5.  J Affect Disord. 2018;234:256-260. doi:10.1016/j.jad.2018.03.001PubMedGoogle ScholarCrossref
29.
Weathers  FW, Bovin  MJ, Lee  DJ,  et al.  The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5): development and initial psychometric evaluation in military veterans.  Psychol Assess. 2018;30(3):383-395. doi:10.1037/pas0000486PubMedGoogle ScholarCrossref
30.
First  MB, Spitzer  RL, Gibbon  M, Williams  JB.  Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. Washington, DC: American Psychiatric Publishing; 2002.
31.
Sobell  LC, Sobell  MB. Timeline follow-back: a technique for assessing self reported alcohol consumption. In: Litten  R, Allen  JP, eds.  Measuring Alcohol Consumption: Psychological and Biochemical Methods. Clifton, NJ: Humana Press; 1992:41-72. doi:10.1007/978-1-4612-0357-5_3
32.
SAS Institute.  SAS/IML Studio 3. 3 for SAS/STAT Users. Cary, NY: SAS Institute; 2010.
33.
McHugh  ML.  Interrater reliability: the kappa statistic.  Biochem Med (Zagreb). 2012;22(3):276-282. doi:10.11613/BM.2012.031PubMedGoogle ScholarCrossref
34.
Sobell  LC, Brown  J, Leo  GI, Sobell  MB.  The reliability of the Alcohol Timeline Followback when administered by telephone and by computer.  Drug Alcohol Depend. 1996;42(1):49-54. doi:10.1016/0376-8716(96)01263-XPubMedGoogle ScholarCrossref
35.
Paterson  DL, Swindells  S, Mohr  J,  et al.  Adherence to protease inhibitor therapy and outcomes in patients with HIV infection.  Ann Intern Med. 2000;133(1):21-30. doi:10.7326/0003-4819-133-1-200007040-00004PubMedGoogle ScholarCrossref
36.
Attkisson  CC, Zwick  R.  The client satisfaction questionnaire: psychometric properties and correlations with service utilization and psychotherapy outcome.  Eval Program Plann. 1982;5(3):233-237. doi:10.1016/0149-7189(82)90074-XPubMedGoogle ScholarCrossref
37.
Hien  DA, Jiang  H, Campbell  ANC,  et al.  Do treatment improvements in PTSD severity affect substance use outcomes? a secondary analysis from a randomized clinical trial in NIDA’s Clinical Trials Network.  Am J Psychiatry. 2010;167(1):95-101. doi:10.1176/appi.ajp.2009.09091261PubMedGoogle ScholarCrossref
38.
Najavits  L, Liese  B.  Seeking Safety Adherence Scale. Version 3. Boston, MA: Harvard Medical School/McLean Hospital; 2003.
39.
Haller  M, Norman  SB, Cummins  K,  et al.  Integrated cognitive behavioral therapy versus cognitive processing therapy for adults with depression, substance use disorder, and trauma.  J Subst Abuse Treat. 2016;62:38-48. doi:10.1016/j.jsat.2015.11.005PubMedGoogle ScholarCrossref
40.
IBM.  IBM SPSS statistics version 21. Boston, MA: International Business Machines Corp; 2012:126.
41.
Hien  DA, Smith  KZ, Owens  M, López-Castro  T, Ruglass  LM, Papini  S.  Lagged effects of substance use on PTSD severity in a randomized controlled trial with modified prolonged exposure and relapse prevention.  J Consult Clin Psychol. 2018;86(10):810-819. doi:10.1037/ccp0000345PubMedGoogle ScholarCrossref
42.
Back  SE, Brady  KT, Jaanimägi  U, Jackson  JL.  Cocaine dependence and PTSD: a pilot study of symptom interplay and treatment preferences.  Addict Behav. 2006;31(2):351-354. doi:10.1016/j.addbeh.2005.05.008PubMedGoogle ScholarCrossref
43.
Read  JP, Brown  PJ, Kahler  CW.  Substance use and posttraumatic stress disorders: symptom interplay and effects on outcome.  Addict Behav. 2004;29(8):1665-1672. doi:10.1016/j.addbeh.2004.02.061PubMedGoogle ScholarCrossref
44.
Myrick  H, Brady  K.  Current review of the comorbidity of affective, anxiety, and substance use disorders.  Curr Opin Psychiatry. 2003;16(3):261-270. doi:10.1097/01.yco.0000069080.26384.d8Google Scholar
45.
Sharkansky  EJ, Brief  DJ, Peirce  JM, Meehan  JC, Mannix  LM.  Substance abuse patients with posttraumatic stress disorder (PTSD): identifying specific triggers of substance use and their associations with PTSD symptoms.  Psychol Addict Behav. 1999;13(2):89-97. doi:10.1037/0893-164X.13.2.89Google ScholarCrossref
46.
Dansky  BS, Brady  KT, Saladin  ME.  Untreated symptoms of PTSD among cocaine-dependent individuals: changes over time.  J Subst Abuse Treat. 1998;15(6):499-504. doi:10.1016/S0740-5472(97)00293-6PubMedGoogle ScholarCrossref
47.
van Minnen  A, Harned  MS, Zoellner  L, Mills  K.  Examining potential contraindications for prolonged exposure therapy for PTSD.  Eur J Psychotraumatol. 2012;3(1):18805. doi:10.3402/ejpt.v3i0.18805PubMedGoogle ScholarCrossref
48.
Najavits  LM, Hamilton  N, Miller  N, Griffin  J, Welsh  T, Vargo  M.  Peer-led seeking safety: results of a pilot outcome study with relevance to public health.  J Psychoactive Drugs. 2014;46(4):295-302. doi:10.1080/02791072.2014.922227PubMedGoogle ScholarCrossref
49.
Kaysen  D, Schumm  J, Pedersen  ER, Seim  RW, Bedard-Gilligan  M, Chard  K.  Cognitive processing therapy for veterans with comorbid PTSD and alcohol use disorders.  Addict Behav. 2014;39(2):420-427. doi:10.1016/j.addbeh.2013.08.016PubMedGoogle ScholarCrossref
50.
Perez-Dandieu  B, Tapia  G.  Treating trauma in addiction with EMDR: a pilot study.  J Psychoactive Drugs. 2014;46(4):303-309. doi:10.1080/02791072.2014.921744PubMedGoogle ScholarCrossref
51.
Sloan  DM, Feinstein  BA, Gallagher  MW, Beck  JG, Keane  TM.  Efficacy of group treatment for posttraumatic stress disorder symptoms: a meta-analysis.  Psychol Trauma. 2013;5(2):176-183. doi:10.1037/a0026291Google ScholarCrossref
52.
Resick  PA, Wachen  JS, Dondanville  KA,  et al; and the STRONG STAR Consortium.  Effect of group vs individual cognitive processing therapy in active-duty military seeking treatment for posttraumatic stress disorder: a randomized clinical trial.  JAMA Psychiatry. 2017;74(1):28-36. doi:10.1001/jamapsychiatry.2016.2729PubMedGoogle ScholarCrossref
53.
Watts  BV, Schnurr  PP, Mayo  L, Young-Xu  Y, Weeks  WB, Friedman  MJ.  Meta-analysis of the efficacy of treatments for posttraumatic stress disorder.  J Clin Psychiatry. 2013;74(6):e541-e550. doi:10.4088/JCP.12r08225PubMedGoogle ScholarCrossref
54.
Back  SE, Killeen  T, Badour  CL,  et al.  Concurrent treatment of substance use disorders and PTSD using prolonged exposure: a randomized clinical trial in military veterans.  Addict Behav. 2019;90:369-377. doi:10.1016/j.addbeh.2018.11.032PubMedGoogle ScholarCrossref
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