Association of Social Determinants of Health and Vaccinations With Child Mental Health During the COVID-19 Pandemic in the US

Key Points

Question  To what extent are individual and structural social determinants of health (SDoH) and vaccinations associated with child mental health during the COVID-19 pandemic?

Findings  In this cohort study of 8493 US children, pandemic-related food insecurity, parental unemployment, disrupted mental health treatment, living in neighborhoods with higher shares of adults working full-time, and living in states lagging in vaccination rates were associated with increased trajectories of perceived stress, sadness, and COVID-19–related worry. Associations between SDoH and these mental health outcomes were more common among Asian, Black, and Hispanic children more than White children.

Meaning  Supporting children’s mental health requires multifaceted policies that address SDoH and structural barriers to food, health services, employment protection, and vaccination.

Importance  The COVID-19 pandemic disproportionately affected mental health in socioeconomically disadvantaged children in the US. However, little is known about the relationship of preexisting and time-varying social determinants of health (SDoH) at individual and structural levels, vaccination eligibility/rates, and the racial and ethnic differences to trajectories of child mental health during the COVID-19 pandemic.

Objective  To estimate the association of trajectories of child mental health to multilevel SDoH and vaccination eligibility/rates.

Design, Setting, and Participants  This prospective longitudinal cohort study, conducted from May 16, 2020, to March 2, 2021, integrated structural-level, pandemic-related data with the Adolescent Brain Cognitive Development (ABCD) cohort data (release 4.0). The ABCD study recruited 11 878 children (baseline) and conducted 6 COVID-19 rapid response surveys across 21 US sites (in 17 states) from May 16, 2020, to March 2, 2021.

Exposures  Preexisting individual (eg, household income) and structural (area deprivation) SDoH and time-varying individual (eg, food insecurity, unemployment) and structural (eg, social distancing, vaccination eligibility/rates) SDoH.

Main Outcomes and Measures  Perceived Stress Scale, the National Institutes of Health–Toolbox emotion measures, and COVID-19–related worry.

Results  The longitudinal sample included 8493 children (mean [SD] age, 9.93 [0.63] years; 5011 girls [47.89%]; 245 Asian [2.34%], 1213 Black [11.59%], 2029 Hispanic [19.39%], 5851 White [55.93%], and 1124 children of other/multiracial ethnicity [10.74%]). Trajectories of stress, sadness, and COVID-19–related worry decreased after adult vaccination rollout. Compared with younger children, boys, White children, or those living with married parents, those who reported greater perceived stress included older children aged 12 to 15 years (β = 0.26; 95% CI, 0.12-0.41; P < .001); girls (β = 0.75; 95% CI, 0.61-0.89; P < .001); Hispanic children (β = 0.24; 95% CI, 0.01-0.47; P = .04); children living with separated parents (β = 0.50; 95% CI, 0.03-0.96; P = .04); children experiencing disrupted medical health care access (β = 0.19; 95% CI, 0.01-0.36; P = .04); children living in economically deprived neighborhoods (β = 0.28; 95% CI, 0.05-0.51; P = .02); children living in areas with more full-time working-class adults who were unable to social distance (β = 1.35; 95% CI, 0.13-2.67; P = .04); and children living in states with fewer fully vaccinated adults (β = 0.59; 95% CI, 0.16-1.02; P = .007). COVID-19 pandemic–related worry was higher among Asian children (β = 0.22; 95% CI, 0.08-0.37; P = .003), Black children (β = 0.33; 95% CI, 0.22-0.43; P < .001), children of other/multiracial ethnicity (β = 0.17; 95% CI, 0.09-0.25; P < .001), and children with disrupted medical health care (β = 0.15; 95% CI, 0.09-0.21) and disrupted mental health treatment (β = 0.11; 95% CI, 0.06-0.16). Inability to afford food was associated with increased sadness (β = 1.50; 95% CI, 0.06-2.93; P = .04). States with later vaccination eligibility dates for all adults were associated with greater COVID-19–related worry (β = 0.16; 95% CI, 0.01-0.31; P = .03) and decreased positive affect (β = −1.78; 95% CI, −3.39 to −0.18; P = .03) among children.

Conclusions and Relevance  Results of this study suggest a disproportionately adverse association of the COVID-19 pandemic with child mental health among racial and ethnic minority groups, which may be improved by addressing modifiable individual (food insecurity, unemployment, health services, parental supervision) and structural (area deprivation, job protection, vaccination) SDoH.

The COVID-19 pandemic elevated mental distress in young and older adults moderated by sociodemographic disparities.^1-4 Few studies have examined the long-term relationship of social determinants of health (SDoH), defined as conditions in which people “…are born, grow, live, work, and age,”^5p(76) during the pandemic to children’s mental health trajectories.^6-9 Multiplicative pandemic-related stressors and trauma from parental loss, school closures, financial uncertainties, and health care disruptions were experienced by children potentially affecting their mental health.^10-14 Children aged 5 to 11 years were the last to receive vaccines (November 2021),¹⁵ and children younger than 5 years are still waiting for vaccine protection, lengthening their uncertainties.^8,13,16 The syndemic of COVID-19, structural racism, and SDoH may interact with and affect mental health disparities in children during COVID-19 and in future public health emergencies.^17-19

SDoH acts as direct risks, moderators, and mediators of mental health disparities at the individual (eg, income) and structural (eg, area deprivation) level (Figure 1).^18-21 Preexisting SDoH underlie long-standing socioeconomic disadvantages.^18,22 Time-varying SDoH highlight pandemic-related food insecurity, loss of parental or teacher supervision (eg, when full-time working parents were unable to work from home), disrupted health care services, and financial hardship.^2,3,22-24 Children may experience more mental health and social changes from the COVID-19 pandemic than adults owing to multidimensional SDoH.^10,14,25 Addressing SDoH can inform multilevel, equitable policy responses to protect child mental health.^19,26

SDoH may affect children from racial and ethnic minority groups differently owing to structural racism in school and residential segregation.^10,11,25,27 Racial differences in adult COVID-19 mortality and positivity are reported in neighborhoods with the same socioeconomic deprivation.^22,28 Belonging to a particular race is not an SDoH. Instead, racial status is a proxy of structural racism that forms the social milieu of mental health disparities.²⁹ Examining the intersection between SDoH, race, and ethnicity can guide meaningful policy solutions to health disparities.

COVID-19–related mental health studies have, to date, focused on adults^3,10,27,30 and neglected children and social-geographic disparities. Few studies (none in children, to our knowledge) used a longitudinal study design measuring individual and structural, time-varying SDoH factors.^8,31,32 Distilling heterogeneity in the associations between prepandemic and postpandemic SDoH risks and short- and long-term child mental health trajectories, provides critical information to design tailored and more effective prevention, treatment, and policies to mitigate race and ethnicity disparities.³²

This study examined the association of preexisting and time-varying SDoH factors, at individual and structural levels, with mental health trajectories among US children, surveyed 6 times between May 2020 and March 2021. We further examined racial and ethnic disparities in SDoH and mental health.

Data for this cohort study were drawn from the Adolescent Brain Cognitive Development (ABCD) study.³³ Baseline data were based on a stratified probability sample of schools from 21 testing sites in the US and 11 878 children recruited from 2016 to 2018. Previous studies^34,35 have detailed ABCD study design. To incorporate individual- and structural-level SDoH, we assembled a longitudinal data set, comprising 6 main components (Figure 2; eMethods 1 and 2 in the Supplement): (1) ABCD COVID-19 Rapid Response Research on child mental health and experiences reported by children and parents/caregivers through 6 wave surveys between May 16, 2020, and April 24, 2021; (2) ABCD COVID-19 geocoded data on individual-level time-varying SDoH³⁶; (3) ABCD child residential history data on structural-level preexisting SDoH; (4) ABCD baseline children’s sociodemographic characteristics (ABCD 4.0 release); (5) dates where all adults aged 18 years or older were eligible for vaccines, cross-referenced from The New York Times³⁷ and US News & World Report³⁸; and (6) the US Centers for Disease Control and Prevention COVID-19 Vaccine Tracker.³⁹ After sample selection (eg, at least 3 repeated measures, eFigure 1 in the Supplement), the study sample contained 44 958 observations. We used all records with available information. The ABCD sample is not nationally representative. However, the ABCD cohort, when compiled with the COVID-19 and geocoded data, enables our examination in multilevel SDoH of mental health in the largest US child sample, tracking 47 weeks during COVID-19, which distinguishes our study from previous investigations. All measures are described in eTable 2 in the Supplement.

All parents/caregivers provided written informed consent and children provided verbal assent to research protocols approved by either a central or local institutional review board. We obtained a data-use certificate from the National Institute of Mental Health Data Archive use agreement. This study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guidelines.

We included 4 mental health measures to capture psychopathology (stress, COVID-19–related worry, sadness) and well-being (positive affect) based on the dual-factor mental health model.⁴⁰

Perceived stress was measured with the 4-item version of the Perceived Stress Scale (PSS).⁴¹ Children were asked for past-month frequency of stressful situations (eg, “How often have you felt that things were going your way?”) on a 5-point Likert scale (from 0 = never to 4 = very often). Two items (Q2, Q4) were reversely scored, and scores were summed on the PSS-4. COVID-19–related worry was measured by 1 question asking children, “How worried have you been about coronavirus (COVID-19)?” on a 5-point Likert scale (from 1 = not at all to 4 = extremely).

Sadness (8 items; eg, feeling lonely, sad, unhappy) and positive affect (9 items; eg, feeling happiness, joy, serenity, peace) were measured using the National Institutes of Health (NIH)–Toolbox emotion battery on a 5-point scale (from 1 = never to 5 = almost always). We followed the NIH-Toolbox Scoring and Interpretation Guide⁴² and calculated the uncorrected standard score (T score). Higher scores represented more stress, COVID-related worry, sadness, and positive affect.

We measured preexisting (long-standing features presented before COVID-19) and time-varying SDoH (pandemic-related changes in conditions) at individual and structural levels based on our theoretical framework (Figure 1).

Preexisting SDoH at the individual level included baseline parent-reported (1) annual household income (<$50 000, $50 000-$100 000, ≥$100 000); (2) highest level of parental education (<bachelor’s degree, ≥bachelor’s degree); and (3) parent marital status (married, widowed, divorced, separated, never married, cohabitated).

At the structural level, we used the census tract–level Area Deprivation Index (ADI), which was calculated from the 2011 to 2015 5-year American Community Survey estimates of children’s baseline residential address. The ADI is a composite-weighted metric of 17 neighborhood disadvantage indicators (eg, poverty, unemployment, family income, low education; eTable 1 in the Supplement). ADI was used because it does not include indirect measures of race and ethnicity, minimizing potential confounding. ADI national percentiles were aggregated into 3 levels: most, intermediate, and least deprived. The original proposed ADI was contributed by the code for computing and merging ADI (and its national percentile) with ABCD data are available at the ABCD Data Analytics and Informatics Resource Center.⁴³

Time-varying SDoH at the individual level included parent-reported COVID-19–related (1) food insecurity (whether their families “needed food but couldn't afford to buy it or couldn't afford to get out to get it?” [cannot afford], and “worried about whether your food would run out before you could get more” [worry about food]), (2) unemployed parents/caregivers (whether there were family members lost wages and/or job owing to COVID-19), and (3) disrupted health care access (how COVID-19 changed their medical health care and mental health treatment access).

At the structural level, SDoH that potentially amplified disparities in child mental health included (1) county-level COVID-19 infection and mortality rates from Center of Systems Science and Engineering at Johns Hopkins University,⁴⁴ (2) census block-level Social Distancing Metrics⁴⁵ from SafeGraph (median distance traveled from home, time at home, devices detected completely at home, part-time and full-time work behaviors were used; all were proxies for the ability to social distance, as essential workers had to travel to work and experienced greater exposure),⁴⁶ and (3) state-level timeline of all adults eligible for vaccination (before April 2021, April 1-14, after April 15, 2021) and rates of fully vaccinated adults (4 quantiles) to account for geographic heterogeneity (eMethods 3 in the Supplement).

Baseline parent-reported children’s demographic characteristics: age (10-11 years, 12-15 years), biological sex (male or female), race and ethnicity (Asian, Black, Hispanic, White, and other/multiracial). The 5-level race and ethnicity variable is consistent with the US Office of Management and Budget (OMB) Standards for presenting data on race and ethnicity.³⁴

Temporal trends were anchored by interview days and survey numbers. Given nonlinear changes in mental distress observed previously and model fit assessment (eMethods 4 in the Supplement),^47-49 interview dates were continuous variables representing the number of days from May 16, 2020, to April 24, 2021 (range, 0-343 days). Categorical survey numbers (1-6) were used for variations in survey launching periods.

Descriptive statistics for the COVID-19 survey sample were compared with the ABCD main sample. Multilevel generalized linear mixed models (GLMM) were used to examine SDoH on child mental health trajectories (eMethods 4 in the Supplement). A multilevel framework is more flexible when incorporating time variation in follow-up waves,^35,50,51 as applied in previous similarly designed studies.⁵² GLMM was fitted to estimate fixed and random effects of intercept (baseline mental health) and slope (change per assessment) by days of follow-up, allowing an unstructured covariance matrix of intercept and slope. Random effects included random intercepts for study site and participant identification, adjusting for the nested nature of ABCD. We did not use the American Community Survey poststratification propensity weights because the purpose of our study was not to obtain population-representative estimates but to examine site-specific SDoH across 17 states (eMethods 5 in the Supplement). Race and ethnicity SDoH interactions were tested because there are racial and ethnic differences in the associations between SDoH and mental health.⁵³

We modeled mental health trajectories using restricted cubic splines with 95% CIs relative to the median. Five knots (5, 27.5, 50, 72.5, 95 percentiles) were created using the Harrell method (eMethods 4 in the Supplement).⁵⁴ Missing data were uncommon. Categorical factors were effects-coded, and continuous factors were centered.⁵⁵ We conducted sensitivity analyses using alternative samples, measures, models (eMethods 6 in the Supplement).⁵⁶ Statistical significance was determined by a 2-sided P value <.05. Analyses and visualization were conducted using Stata, version 17 (StataCorp), R (R Foundation for Statistical Computing), and Python, version 3.9 (Python Software Foundation).

At baseline, the longitudinal sample included 8493 children (mean [SD] age, 9.93 [0.63] years; 5011 girls [47.89%]; 3482 boys [41.00%]; 245 Asian [2.34%], 1213 Black [11.59%], 2029 Hispanic [19.39%], 5851 White [55.93%], and 1124 children of other/multiracial ethnicity [10.74%]). A total of 4544 children (47.23%) lived in lower-income families (<$50 000 per year), and 1709 children (31.15%) lived in the most economically deprived areas (Table). Black children disproportionately lived in the most economically deprived areas (eFigure 2 in the Supplement). Compared with the overall ABCD sample, the COVID-19 Rapid Response Research sample contained more White children, children with married parents, children with parents/caregivers with a bachelor’s degree, and children living in higher-income families (>$100 000 per year) and less-deprived areas (ie, bottom 30% of the ADI, representing less poverty and better educated residents). There were decreases in children worried about food (from 1714 [17.53%] to 901 [13.15%]) and families who cannot afford food (from 600 [6.15%] to 320 [4.68%]), but persistently high rates of COVID-19 pandemic–related unemployed parents/caregivers and disrupted health care service access. Social distancing decreased from May 2020 to August 2020 but subsequently increased until the end of 2020 before a second decrease. Approximately 43% (3158 of 7320) of children lived in states where all adults were eligible for vaccination from April 1 to April 14, 2021, and 30% (2411 of 7320) lived in states ranked in the second quantile of fully vaccinated adult rates.

The mean (SD) of perceived stress and sadness scores declined from survey 1 during May 16, 2020 (5.57 [2.97]), to May 22, 2020 (49.34 [10.99]), to survey 3 during August 4, 2020 (5.08 [2.81]), to August 5, 2020 (48.30 [11.11]). The mean of COVID-19–related worry and positive affect decreased steadily over time (Table).

Estimated values from restricted cubic spline regressions revealed distinct mental health trajectories (Figure 3). Predicted perceived stress and COVID-19–related worry declined from May to August 5, 2020, increased in the fall of 2020, but decreased continuously after adult vaccination started (December 13, 2020). Children’s sadness increased in the first survey (May 22-June 27, 2020), decreased during the summer of 2020, rose in the fall to a peak around December 2020, and then decreased.

An adjusted GLMM (Figure 4 and eTable 3 in the Supplement) found that older children aged 12 to 15 years (β = 0.26; 95% CI, 0.12-0.41; P < .001), girls (β = 0.75; 95% CI, 0.61-0.89; P < .001), Hispanic children (β = 0.24; 95% CI, 0.01-0.47; P = .04), children living with separated parents (β = 0.50; 95% CI, 0.03-0.96; P = .04), and children living in the most economically deprived neighborhoods (β = 0.28; 95% CI, 0.05-0.51; P = .02) reported increasing and greater stress than children who were younger, boys, White, or living with married parents. Older children (β = 0.78; 95% CI, 0.15-1.41; P = .02), girls (β = 4.12; 95% CI, 3.50-4.74; P < .001), and children living with separated parents (β = 2.20; 95% CI, 0.09-4.30; P = .04) had more NIH-Toolbox sadness. Compared with White children, COVID-19 pandemic–related worry was higher among Asian children (β = 0.22; 95% CI, 0.08-0.37; P = .003), Black children (β = 0.33; 95% CI, 0.22-0.43; P < .001), children of other/multiracial ethnicity (β = 0.17; 95% CI, 0.09-0.25; P < .001), and children with disrupted medical health care (β = 0.15; 95% CI, 0.09-0.21) and disrupted mental health treatment (β = 0.11; 95% CI, 0.06-0.16).

Higher stress scores were associated with disrupted access to medical health care (β = 0.19; 95% CI, 0.01-0.36; P = .04) and to mental health treatment (β = 0.65; 95% CI, 0.50-0.81; P < .001), and with living in communities with more full-time working adults (β = 1.35; 95% CI, 0.13-2.67; P = .04). Children living with families unable to afford needed food (β = 1.50; 95% CI, 0.06-2.93; P = .04) experienced higher and increasing trajectories of sadness.

Living in states with lower fully vaccinated rates was associated with increasing stress (β = 0.59; 95% CI, 0.16-1.02; P = .007), increasing NIH-Toolbox sadness (β = 2.34; 95% CI, 0.47-4.21; P = .01), and decreasing NIH-Toolbox positive affect (β = −1.90; 95% CI, −3.53 to −0.26; P = .02). Living in states with later dates for all adults being eligible for vaccination was associated with increased COVID-19–related worry (β = 0.16; 95% CI, 0.01-0.31; P = .03) and decreased positive affect (β = −1.78; 95% CI, −3.39 to −0.18; P = .03).

Restricted cubic spline regressions stratified by race, ethnicity, and SDoH indicated steeper increases in perceived stress trajectories in older Hispanic children, children living in deprived areas, experiencing food insecurity, and households with unemployed parent/caregivers (eFigures 3-5 in the Supplement).

We observed race-SDoH interaction associations for 4 mental health outcomes (eFigures 6-25 in the Supplement): steeper increases in COVID-19–related worry in Black and Hispanic children and children of other/multiracial ethnicity whose parents had less than bachelor’s degrees (eFigure 7 in the Supplement), Black and Hispanic children living in lower-income households (<$50 000 per year, eFigure 6 in the Supplement), and Black children living in the most deprived neighborhoods (eFigure 9 in the Supplement). Asian children whose families could not afford food had a steeper increase in perceived stress and sadness than White children (eFigure 11 in the Supplement). Hispanic children reported decreased sadness (β = −3.20; 95% CI, −5.93 to −0.47; P = .02) and increased positive affect (β = 4.03; 95% CI, 1.01-7.04; P = .009) when living in states where adults became eligible for vaccines earlier (eFigure 24 in the Supplement). Black children reported a steeper increase in COVID-19–related worry if they were from states lagging in vaccinations (eFigure 25 in the Supplement). Our findings proved robust in sensitivity analyses (eMethods 6 in the Supplement).

In this cohort study, we found that children experienced decreasing-increasing trajectories of stress and sadness from May 16 to December 12, 2020, followed by a consistent decrease after December 13, 2020, which coincided with vaccination rollout and new government policies for health and the economy beginning in January 2021. Preexisting (living in deprived areas) and time-varying (food insecurity, unemployed family members, disrupted health care, living in neighborhoods with more adults working full-time away from home, vaccinations) SDoH and race-SDoH interactions were associated with child mental health disparities.

Trajectories of stress and COVID-19–related worry were associated with time-varying SDoH. Previous studies reported greater depression in adults experiencing food insecurity.^57-59 We found that children in households experiencing food insecurity also had increasing sadness and decreasing positive affect.⁶⁰ Public health policies should consider improving nutritional assistance programs, such as the Supplemental Nutrition Assistance Program and Women, Infants, and Children, expanding the amount and duration of unemployment insurance and housing subsidies, extending eviction moratoriums,⁴ and increasing universal minimum-wage to reduce food insecurity for improving child mental health.^60,61

Children who experienced disrupted medical health care and mental health treatment reported worsening mental health outcomes. School closures, lack of access to telehealth, and disrupted community-based pediatric care may contribute to adverse child mental health.²³ Expanding health care insurance coverage, minimizing cost-sharing (out-of-pocket expense), supporting community behavioral health facilities, improving value-based care, and developing broadband infrastructure to expand telehealth may reduce inequalities.⁶²

Children living in areas with more adults working full-time, a possible proxy for a higher concentration of essential workers and inability to work from home,⁶³ reported greater stress. Low-wage essential workers had fewer employment protections (eg, fewer paid sick leave, lack of unemployment insurance, risk of COVID-19 exposures while on the job).⁶⁴ This additional stress may have affected their children.⁵² Neighborhoods with high full-time working rates may have been low-income areas with greater racial and ethnic disparities in COVID-19 infections/mortality, barriers to social distancing, and vaccination uptake owing to lack of trust in health directives and structural racism.⁶⁵ Public policies should address the needs of under-resourced communities, minoritized households, and parents who were essential workers. Basic needs, such as paid sick leave, expanded insurance coverage, employment protection, financial assistance, Earned Income Tax Credit, and rent stabilization, should be considered along with childcare resources and direct food assistance.^4,65

This is the first study, to our knowledge, that found a possible association between children’s mental health and adult COVID-19 vaccination.⁶⁶ Less anxiety and depression were observed in adults in US states with higher COVID-19 vaccination rates.⁶⁷ This suggests the potential benefit of vaccinations extends to child mental health.³⁰ States with more vaccinated adults may indicate better health literacy, trust in vaccines, and earlier and equitable access to vaccination.⁶⁸ Vaccination acts as a pandemic-related structural SDoH for child mental health by potentially reducing uncertainty, fear, and stress, while improving health outcomes in vaccinated people.²¹

Within the syndemics of COVID-19, SDoH, and structural racism, there are intersectional risks on child mental health trajectories by race and ethnicity. Black and Hispanic children reported greater stress, sadness, and COVID-19–related worry when living in economically deprived areas and having families with food insecurity and unemployed parents (Figure 4 and eTable 3 in the Supplement). Differences in risk and resilience profiles owing to racism and structural inequities demand health and economic policy adjustments.^69,70 Discrimination, racism, and bias may magnify the association of SDoH with child mental health disparities as indicated in previous ABCD studies in baseline⁷¹ and during the COVID-19 pandemic.⁷² After a call from the US Surgeon General,⁷³ it is imperative to systematically quantify, uncover, and deconstruct the multilevel and intersectional mechanisms of disparities to inform nuanced solutions to mental health disparities in children.

This study highlighted the importance of long-term investigation of the trajectories of children’s mental health given the ongoing pandemic, multilevel SDoH, and stressors/trauma that may be associated with child mental health. Older children; girls; Asian, Black, and Hispanic children; children of other/multiracial ethnicity; children who experienced food insecurity and disrupted health care access; and children living in economically deprived areas, areas with high full-time work behaviors, and low vaccination rates have disproportionate outcomes associated with the COVID-19 pandemic. Future research should address key time-varying (eg, food insecurity, full-time/part-time working conditions) and mechanistic pathways linking SDoH and children’s mental health trajectories when future waves of data become available. There is a need for studies in children and parents to understand factors associated with perceived stress, sadness, and worry.

Clinicians, psychiatrists, and social work practitioners should consider the SDoH of child mental health during the COVID-19 pandemic and partner with community agencies to address the structural barriers. Integrating structural competency and clinical practice may facilitate institutional and policy interventions to bridge the gap between SDoH and clinical strategies.⁷⁴ Multipronged, upstream, and equity-responsive approaches are needed to reduce structural barriers to food, mental health services, housing, and employment benefits.⁵⁷

Study strengths included the use of large, population-based, longitudinal data measuring child mental health outcomes repeatedly over 47 weeks during the COVID-19 pandemic. The study extended previous knowledge about children’s mental health under COVID-19 by linking individual-level and structural-level SDoH and incorporating time-varying factors that capture pandemic-related dynamics.

This study also had limitations. ABCD measures are self-reported, subject to social desirability and recall biases. Biases were mitigated using multiple mental health measures (eg, PSS, NIH Toolbox). Second, there are multiple interaction effects within SDoH and between SDoH, race, ethnicity, sex, and other health disparity status.⁷² Other psychological disorders and brain development factors are potentially important. We could not include all possible factors as our main purpose was to evaluate the SDoH relationship with child mental health disparities. Third, data on child mental health between the appearance of COVID-19 in the US (December 2019) and the start of school closure, were not available. Future studies are needed to reproduce time-varying SDoH influences in larger populations to be generalized to the entire US child population.

Results of this cohort study suggest a disproportionately adverse association of the COVID-19 pandemic with child mental health among racial and ethnic minority groups, which may be improved by addressing modifiable individual (food insecurity, unemployment, health services, parental supervision) and structural (area deprivation, job protection, vaccination) SDoH.

Identifying and addressing preexisting and time-varying social determinants of mental health in children, in tandem with empowering the most marginalized populations and communities, appear critical for addressing mental health disparities. Children from families facing food insecurity, disrupted health care access, living in areas with greater full-time working behaviors, and lower vaccination rates, experienced adverse mental health outcomes. Public policies targeting food assistance, unemployment insurance, worksite parental leave policies, and health care access may lead to more sustainable and equitable paths to reduce mental health disparities. Child mental health was associated with an improvement at the time of adult vaccine rollout. Enhancing vaccination uptake through place-based allocations, targeted community outreach, and investment to reduce structural barriers and build trust, may potentially improve child mental health.

Accepted for Publication: March 1, 2022.

Published Online: April 27, 2022. doi:10.1001/jamapsychiatry.2022.0818

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2022 Xiao Y et al. JAMA Psychiatry.

Corresponding Author: Yunyu Xiao, PhD, Department of Population Health Sciences, Weill Cornell Medicine, New York–Presbyterian, Division 306, 425 E 61 St, New York, NY 10065 (yux4008@med.cornell.edu).

Author Contributions: Dr Xiao had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: Xiao, Pathak, Mann.

Drafting of the manuscript: Xiao, Pathak.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Xiao, Yip.

Obtained funding: Xiao.

Administrative, technical, or material support: Xiao, Pathak.

Supervision: Pathak, Mann.

Conflict of Interest Disclosures: Dr Xiao reported receiving grants from the Bill & Melinda Gates Foundation during the conduct of the study. Dr Mann reported receiving royalties for commercial use of the Columbia Suicide Severity Rating Scale paid from the Research Foundation for Mental Hygiene. No other disclosures were reported.

Funding/Support: This research is supported by grant CORONAVIRUSHUB-D-21-00125 from the Bill & Melinda Gates Foundation and a Research Grants Council Collaborative Research Fund grant (C7151-20G) from the University Grants Committee of Hong Kong.

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.