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This Month in Archives of General Psychiatry
February 2004

This Month in Archives of General Psychiatry

Arch Gen Psychiatry. 2004;61(2):115. doi:10.1001/archpsyc.61.2.115

Ford et al Article combinedevent-related brain potentials and functional magnetic resonance imaging toassess brain regions involved in inhibition of prepotent responses in patientswith schizophrenia. Healthy control subjects established a strong responsebias that was inhibited by engaging a complex neural system involving thecingulate cortex and prefrontal and inferior parietal lobes. Patients withschizophrenia established a weaker response bias that was inhibited by engagingonly the cingulate cortex.

McGowan et al Article haveassessed presynaptic dopaminergic function in medicated patients with schizophreniawith a high-sensitivity 18F-fluorodopa 3-dimensional positron emissiontomography protocol. Statistical parametric mapping and region of interestanalyses showed increased 18F-fluorodopa uptake, primarily in theventral striatum, in patients with schizophrenia compared with control subjects.The magnitude of the increases was similar to that reported in unmedicatedpatients with schizophrenia, suggesting that presynaptic striatal dopaminergicfunction remains elevated in the illness despite treatment.