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This Month in Archives of General Psychiatry
April 2004

This Month in Archives of General Psychiatry

Arch Gen Psychiatry. 2004;61(4):333. doi:10.1001/archpsyc.61.4.333

Williams et al Article report a haplotype ofthe gene encoding dystrobrevin binding protein (DTNBP1)associated with increased risk of schizophrenia and 2 haplotypes associatedwith reduced risk in more than 700 control subjects and subjects with schizophreniafrom the United Kingdom. The authors were able to replicate these findingsin independent samples from Ireland. The common protective haplotype was alsoassociated with higher education achievement, suggesting that the effect ofthis haplotype may be mediated by an influence on intelligence.

To determine the magnitudes of the genetic and environmental contributionsto hippocampal volume reduction in schizophrenia, van Erp et al Article appliedmixed-model regression, intraclass correlation, and variance components analysesto hippocampal volumes of twins with schizophrenia and matched healthy controltwins, as measured from high-resolution magnetic resonance imaging results.Hippocampal volumes in the healthy twins appeared to be highly heritable (ie,h2 = 71%), whereas those in twins discordant for schizophreniawere also heritable (ie, h2 = 42%) but were subject to greatermodulation by environmental factors compared with healthy twins.