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This Month in Archives of General Psychiatry
June 2004

This Month in Archives of General Psychiatry

Arch Gen Psychiatry. 2004;61(6):538. doi:10.1001/archpsyc.61.6.538-a

Weickert et al Article mappedthe expression of dysbindin, a schizophrenia susceptibility gene, in postmortembrains from individuals with schizophrenia and suitable controls. They observedreduced levels of dysbindin messenger RNA in the frontal cortex and midbrain,2 regions in which dopaminergic processes are prominent.

Rosa-Neto et al Article measuredan index of serotonin synthesis, brain regional α-[11C] methyl-L-tryptophan trapping (K*, milliliters per gram per minute), in theareas involved in the regulation of mood in medication-free patients witha current episode of major depression. Compared with healthy men and women,normalized K* values were significantly decreased in the anterior cingulateand mesial temporal lobe. The results suggest that reduced serotonin synthesisin parts of the limbic and paralimbic cortices may contribute to the developmentand expression of major depression.