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Foley DL, Eaves LJ, Wormley B, et al. Childhood Adversity, Monoamine Oxidase A Genotype, and Risk for ConductDisorder. Arch Gen Psychiatry. 2004;61(7):738–744. doi:https://doi.org/10.1001/archpsyc.61.7.738
Very little is known about how different sets of risk factors interact
to influence risk for psychiatric disorder.
To replicate a recent report of a genotype-environment interaction that
predicts risk for antisocial behavior in boys.
Characterizing risk for conduct disorder in boys in association with
monoamine oxidase A genotype and exposure to familial adversity, defined by
interparental violence, parental neglect, and inconsistent discipline.
A community-based sample of twin boys.
Five hundred fourteen male twins aged 8 to 17 years.
Main Outcome Measure
There was a main effect of adversity but not of monoamine oxidase A
on risk for conduct disorder. Low monoamine oxidase A activity increased risk
for conduct disorder only in the presence of an adverse childhood environment.
Neither a passive nor an evocative genotype-environment correlation accounted
for the interaction.
This study replicates a recent report of a genotype-environment interaction
that predicts individual variation in risk for antisocial behavior in boys.
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