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This Month in Archives of General Psychiatry
October 2004

This Month in Archives of General Psychiatry

Arch Gen Psychiatry. 2004;61(10):970. doi:10.1001/archpsyc.61.10.970

McDonald et al Article assessedthe neuroanatomical phenotypes of schizophrenia and bipolar disorder by analyzingthe association between a measure of genetic risk in multiply affected familiesand variation in regional tissue volume. Gray matter endophenotypes were distinct,with genetic risk for schizophrenia linked to distributed frontotemporal-subcorticaldeficits, and for bipolar disorder, to localized deficit in emotional processingregions. However, white matter endophenotypes were overlapping, implicatingleft frontotemporal anatomical dysconnectivity as a genetic endophenotypefor psychosis in general.

Using data from 6 countries, Messias et al Article found that patients with deficit schizophrenia, whohave primary and enduring negative symptoms, have an excess of summer births.The finding is consistent with the hypothesis that deficit schizophrenia isa separate disease within the syndrome of schizophrenia.