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Breslau N, Peterson EL, Schultz LR. A Second Look at Prior Trauma and the Posttraumatic Stress Disorder Effects of Subsequent Trauma: A Prospective Epidemiological Study. Arch Gen Psychiatry. 2008;65(4):431–437. doi:10.1001/archpsyc.65.4.431
Previous studies showed increased probability of a posttraumatic stress disorder (PTSD) effect of trauma in persons who had experienced prior trauma. The evidence comes chiefly from retrospective data on earlier events, obtained from trauma-exposed persons with and without PTSD. A generally overlooked major limitation is the failure to assess the PTSD response to the prior trauma.
To estimate the risk of PTSD after traumas experienced during follow-up periods in relation to respondents' prior traumatic events and PTSD.
A cohort study of young adults interviewed initially in 1989,
with repeated assessments during a 10-year follow-up.
Setting and Participants
The sample was randomly selected from a large health maintenance organization in Southeast Michigan, representing the geographic area.
Main Outcome Measures
The relative risk of PTSD precipitated by traumatic events occurring during follow-up periods in relation to prior exposure and PTSD that had occurred during preceding periods, estimated by general estimating equations (n = 990).
The conditional risk of PTSD during the follow-up periods was significantly higher among trauma-exposed persons who had experienced prior PTSD, relative to those with no prior trauma (odds ratio, 3.01;
95% confidence interval, 1.52-5.97). After adjustment for sex, race,
education, and preexisting major depression and anxiety disorders,
the estimates were only marginally revised. In contrast, the conditional risk of PTSD during follow-up among trauma-exposed persons who had experienced prior traumatic events but not PTSD was not significantly elevated, relative to trauma-exposed persons with no prior trauma.
The difference between the 2 estimates was significant (P = .005).
Prior trauma increases the risk of PTSD after a subsequent trauma only among persons who developed PTSD in response to the prior trauma.
The findings suggest that preexisting susceptibility to a pathological response to stressors may account for the PTSD response to the prior trauma and the subsequent trauma.
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