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This Month in Archives of General Psychiatry
July 7, 2008

This Month in Archives of General Psychiatry

Arch Gen Psychiatry. 2008;65(7):743. doi:10.1001/archpsyc.65.7.743

In first-episode schizophrenic patients, Koo et al(page 746) found initially smaller volumes of subgenual, affective, and cognitive components of anterior cingulate, which showed an approximately 6% further volume reduction 1½ years later. In contrast, first-episode affective psychosis patients (mainly bipolar) showed initial and progressive volume reductions only in the subgenual region.

Bertelsen et al (page762) report a single-blinded 5-year follow-up of a randomized controlled 2-year trial of intensive early intervention vs standard treatment for patients with a first episode of psychosis. The experimental treatment improved clinical outcome after 2 years, but the effects were not sustainable up to 5 years after.