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This Month in Archives of General Psychiatry
November 3, 2008

This Month in Archives of General Psychiatry

Arch Gen Psychiatry. 2008;65(11):1243. doi:10.1001/archpsyc.65.11.1243

In a large population-based study of first-onset psychoses in the United Kingdom, Coid et alArticle demonstrated that the incidence rates of several psychotic syndromes were elevated for both first- and second-generation immigrants, but the exact magnitude of risk was conditional on ethnic group.

In a longitudinal study in monozygotic and dizygotic twin pairs discordant for schizophrenia, Brans et alArticle investigated whether genetic and/or environmental factors are associated with progressive brain volume changes. Both patients with schizophrenia and their unaffected co-twins showed significant decreases over time in whole-brain and frontal and temporal lobe volumes. Moreover, additive genetic influences on schizophrenia liability and progressive brain volume changes were found.