In a 2-center, randomized, controlled, assessor-blind, parallel group trial, Moritz and coauthors examine the long-term efficacy of group metacognitive training for schizophrenia in order to explore whether previously established effects were sustained.
Tao et al characterize ZNF804A expression in human brain and investigate how it changes across the life span and how it is affected by rs1344706, schizophrenia, bipolar disorder, and major depressive disorder.
Khandaker et al test the hypothesis that higher serum levels of interleukin 6 and C-reactive protein in childhood would increase future risks for depression and psychosis.
Bernert et al examine the relative independent risk for suicide associated with poor subjective sleep quality in a population-based study of older adults during a 10-year observation period. Four hundred controls were matched to 20 suicide decedents. Primary measures included the Sleep Quality Index, a depression scale, and vital statistics.
Cullen et al examine amygdala resting-state functional connectivity in adolescents with and without MDD using rsfMRI and how amygdala resting-state functional connectivity relates to a broad range of symptom dimensions.
Singh and coauthors examine anomalous neural processing of reward in children at familial risk for bipolar disorder.
Hollon et al determine the effects of combining cognitive therapy with antidepressant medications vs antidepressant medications alone on remission and recovery in major depressive disorder. See the editorial by Thase.
Hauser et al determine the impaired decision-making and learning mechanisms in adolescents with attention-deficit/hyperactivity disorder using advanced computational models, as well as the related neural reward prediction error processes using multimodal neuroimaging.
Liberzon et al examine the association of 3755 candidate gene SNPs with PTSD development in interaction with a history of childhood trauma. They performed a genetic association study in an Ohio National Guard longitudinal cohort, with replication in an independent Grady Trauma Project (Atlanta, Georgia) civilian cohort.
Lautner et al evaluate whether the apolipoprotein E genotype affects the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease (AD) and whether the association of the ε4 allele with biomarkers depends on cortical β-amyloid status.