This prospective controlled study reports that corticostriatal functional dysconnectivity in psychosis is a state-dependent phenomenon. Increased functional connectivity of the striatum with prefrontal and limbic regions may be a biomarker for improvement in symptoms associated with antipsychotic treatment.
This meta-analysis of 6 placebo-controlled studies examines whether the baseline severity of schizophrenia influences the efficacy of antipsychotic drugs.
This randomized clinical trial reports that problem adaptation therapy was more efficacious than supportive therapy for cognitively impaired patients in reducing depression and disability. Problem adaptation therapy may provide relief to a large group of depressed and cognitively impaired older adults with few treatment options.
This quasi-experimental study shows that a mental health intervention integrated into an employment training program can reduce depressive symptoms and improve engaged coping strategies in adolescents and young adults.
This prospective longitudinal study provides evidence that structural abnormalities in anterior insula volume are related to the neurobiology of depressive disorders starting in early childhood.
This US Army study found a high concentration of risk of suicide and other adverse outcomes among soldiers after psychiatric hospitalization.
This pragmatic effectiveness trial finds that telemedicine-based collaborative care can successfully engage rural veterans in evidence-based psychotherapy to improve outcomes of posttraumatic stress disorder (PTSD).
This longitudinal study determines that response to cognitive behavioral therapy (CBT) can be predicted on an individual-patient level based on functional neuroimaging data in panic disorder and agoraphobia.
This retrospective quantification and assessment of temporal patterns of DSM-IV diagnoses not otherwise specified among youth finds that subthreshold diagnoses have expanded, a trend that will continue in the DSM-5 era.
This prospective longitudinal study shows that, although prevalence rates of psychiatric comorbidity decreased in youth after detention, rates remained substantial and were higher than rates in the most comparable studies of the general population.