This Viewpoint discusses the differences between patients experiencing denial and those exhibiting lack of insight and addresses interventions that may improve care for patients exhibiting lack of insight.
This meta-analysis identified a concordance across psychiatric diagnoses in terms of integrity of an anterior insula/dorsal anterior cingulate–based network, which may relate to executive function deficits observed across diagnoses.
This positron emission tomographic functional magnetic resonance imaging study found in vivo evidence for a deficit in the capacity for dopamine release in the dorsolateral prefrontal cortex in schizophrenia.
This cross-sectional study demonstrates that psychiatric comorbidities are common among individuals with Tourette syndrome and that most comorbidities begin early in life.
This meta-analysis suggests that mental disorders rank among the most important causes of death worldwide.
This latent class analysis of obsessive-compulsive (OC) features, cross-sectional tests of association, and classic twin genetic analysis finds phenotypic and genetic overlap between OC and pathological gambling.
This observational study finds reduced effective connectivity in resting-state functional magnetic resonance imaging between key networks involved in attention and interoception in melancholia.
This population-based study of national health registries in Denmark finds that Tourette syndrome/chronic tic disorder (TS/CT) and obsessive-compulsive disorder (OCD) cluster in families, with a higher familial aggregation for TS/CT.
This neuroimaging study suggests that abnormal uncinate fasciculus and cingulum white matter structure may underlie emotional, but not behavioral, dysregulation in pediatric psychiatric disorders.
This prospective longitudinal cohort study determines whether early cognitive decline is associated with risk of psychotic disorder in patients with 22q11.2 deletion syndrome.
This proof-of-principle study demonstrated that genomic biomarkers with very good sensitivity and specificity for boys with autism spectrum disorder in general pediatric settings can be identified.
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