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February 2019 - July 1959




December 2018, Vol 75, No. 12, Pages 1209-1304

In This Issue of JAMA Psychiatry


Abstract Full Text
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JAMA Psychiatry. 2018;75(12):1209. doi:10.1001/jamapsychiatry.2017.3012

City Living and Psychotic Disorders—Implications of Global Heterogeneity for Theory Development

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1211-1212. doi:10.1001/jamapsychiatry.2018.2640

This Viewpoint articulates the need for expanded epidemiological and anthropological research into the risk of psychotic disorders associated with urban living.


A Biology-First Approach in Perinatal Pharmacoepidemiology of Autism: Potential and Pitfalls

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1213-1214. doi:10.1001/jamapsychiatry.2018.2725

Can Better Cardiovascular Care Close the Mortality Gap for People With Schizophrenia?

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1215-1216. doi:10.1001/jamapsychiatry.2018.2726

This editorial comments on recent data that show a mortality gap between individuals with and without schizophrenia, with changes in the disparity as the amount of medical care given increases.

Original Investigation

Association of Autism Spectrum Disorder With Prenatal Exposure to Medication Affecting Neurotransmitter Systems

Abstract Full Text
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JAMA Psychiatry. 2018;75(12):1217-1224. doi:10.1001/jamapsychiatry.2018.2728

This population-based case-control study investigates the association of prenatal exposure to medications that interfere with different neurotransmitter systems with the risk of autism spectrum disorders in offspring in a birth cohort of individuals with and without the disorder.

Association of Depression With Risk of Incident Systemic Lupus Erythematosus in Women Assessed Across 2 Decades

Abstract Full Text
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JAMA Psychiatry. 2018;75(12):1225-1233. doi:10.1001/jamapsychiatry.2018.2462

This longitudinal cohort study of nearly 200 000 women participating for 20 years in the Nurses’ Health Study and the Nurses’ Health Study II assesses whether an association exists between depression and risk of incident systemic lupus erythematosus.

Association of Secondary Preventive Cardiovascular Treatment After Myocardial Infarction With Mortality Among Patients With Schizophrenia

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1234-1240. doi:10.1001/jamapsychiatry.2018.2742

This study uses the Danish nationwide health care registries to investigate the association of secondary preventive cardiovascular treatment with all-cause mortality after myocardial infarction in patients with schizophrenia compared with those without schizophrenia.

Association of Neuroimaging Measures of Emotion Processing and Regulation Neural Circuitries With Symptoms of Bipolar Disorder in Offspring at Risk for Bipolar Disorder

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1241-1251. doi:10.1001/jamapsychiatry.2018.2318

This cross-sectional, longitudinal study examines neuroimaging measures of emotion processing and regulation neural circuitries with symptoms of bipolar disorder in offspring of parents with bipolar disorder compared with offspring of parents with non–bipolar disroder psychopathologies and offspring of healthy parents.

Association of Age at Onset and Longitudinal Course of Prefrontal Function in Youth With Schizophrenia

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1252-1260. doi:10.1001/jamapsychiatry.2018.2538

This naturalistic functional magnetic resonance imaging study examines the association of age at onset and longitudinal course of prefrontal activity in youths with early-onset schizophrenia compared with age-matched healthy control individuals.

Effect of Damaging Rare Mutations in Synapse-Related Gene Sets on Response to Short-term Antipsychotic Medication in Chinese Patients With Schizophrenia: A Randomized Clinical Trial

Abstract Full Text
open access
JAMA Psychiatry. 2018;75(12):1261-1269. doi:10.1001/jamapsychiatry.2018.3039

This randomized clinical trial examines genes and gene sets using exome sequencing technology to determine the genetic mechanism behind the responses to antipsychotic drugs prescribed to patients with schizophrenia.

The Latent Structure of Negative Symptoms in Schizophrenia

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1271-1279. doi:10.1001/jamapsychiatry.2018.2475

This cross-sectional study used confirmatory factor analysis to evaluate the fit of 4 models regarding the latent structure of negative symptoms using confirmatory factor analysis in a population of outpatients with schizophrenia.

Invited Commentary

Successes and Challenges in Precision Medicine in Psychiatry

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1269-1270. doi:10.1001/jamapsychiatry.2018.2897
Special Communication

The Development of Kraepelin’s Mature Diagnostic Concepts of Paranoia (Die Verrücktheit) and Paranoid Dementia Praecox (Dementia Paranoides): A Close Reading of His Textbooks From 1887 to 1899

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1280-1288. doi:10.1001/jamapsychiatry.2018.2377

This article describes the development of categories of mental illness by Emil Kraepelin in the second through sixth editions of his textbook Psychiatrie: Ein Lehrbuch für Studierende und Ärzte.


The Science of Prognosis in Psychiatry: A Review

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1289-1297. doi:10.1001/jamapsychiatry.2018.2530

This narrative review presents an approach to incorporating clinical risk prediction models in psychiatry, highlights challenges, and provides recommendations to improve understanding of prognosis in psychiatry.

JAMA Psychiatry Clinical Challenge

A Case of a College Student Presenting With Mild Mental Health Problems

Abstract Full Text
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JAMA Psychiatry. 2018;75(12):1298-1299. doi:10.1001/jamapsychiatry.2018.2486

A college student presents to a psychosis early-detection clinic with declined functioning and social withdrawal. What would you do next?

Comment & Response

Urbanicity and Psychosis

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1301. doi:10.1001/jamapsychiatry.2018.2347

Urbanicity and Psychosis—Reply

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1301-1302. doi:10.1001/jamapsychiatry.2018.2352

Precision Psychiatry—Yes, but Precisely What?

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JAMA Psychiatry. 2018;75(12):1302-1303. doi:10.1001/jamapsychiatry.2018.2651

Precision Psychiatry—Yes, But Precisely What?—Reply

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1303. doi:10.1001/jamapsychiatry.2018.2656

Disclosures Can Always Be Improved

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1303. doi:10.1001/jamapsychiatry.2018.2780

Disclosures Can Always Be Improved—Reply

Abstract Full Text
JAMA Psychiatry. 2018;75(12):1303-1304. doi:10.1001/jamapsychiatry.2018.2785

Errors in Statistical Test Results, Figure 2, and eFigure 3

Abstract Full Text
free access
JAMA Psychiatry. 2018;75(12):1304. doi:10.1001/jamapsychiatry.2018.3584

Error in Table 2

Abstract Full Text
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JAMA Psychiatry. 2018;75(12):1304. doi:10.1001/jamapsychiatry.2018.3460

Error in Figure

Abstract Full Text
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JAMA Psychiatry. 2018;75(12):1304. doi:10.1001/jamapsychiatry.2018.3755
JAMA Psychiatry Masthead

JAMA Psychiatry

Abstract Full Text
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JAMA Psychiatry. 2018;75(12):1210. doi:10.1001/jamapsychiatry.2017.3013