This Viewpoint discusses the potential therapeutic utility of methylenedioxy-methamphetamine and psilocybin and outlines mental health care infrastructures that would need to be put in place should these drugs be approved for treatment.
This Viewpoint describes why research methods may obscure beneficial approaches to clinical care for patients with suicide-related behaviors.
This randomized clinical trial compares the efficacy of infliximab therapy vs placebo in improving depressive symptoms among adults with bipolar depression in Canada and the United States.
This randomized clinical trial of veterans compares the efficacy of integrated prolonged exposure therapy with present-centered integrated coping skills therapy in reducing posttraumatic stress disorder (PTSD) symptoms and alcohol use.
This cohort study of adolescent girls evaluates the association of hospitalization for infections and treatment with anti-infective agents with the risk of an eating disorder diagnosis in Danish adolescent girls.
This analysis of national Medical Expenditure Panel Survey data examines trends in outpatient treatment of depression in the United States from 1998 to 2015.
This case-control study examines the variables that affect depression among individuals of European ancestry in the UK Biobank study who carry copy number variants associated with neurodevelopmental disorders.
This study examines participant data from the National Institute of Mental Health family study in the United States and the PsyCoLaus family study in Lausanne, Switzerland, for underlying mental disorders and history of suicidal behavior among adults in the same family.
This population-based cohort study assesses whether maternal polygenic risk scores for neurodevelopmental disorders are associated with early-life exposures previously linked to the disorders in women with available genotype data.
This cohort study assesses association of the type and age of exposure to childhood maltreatment with hyperactive and hypoactive amygdala responses in young adults.
This cross-sectional study explores dopamine transporter availability in individuals with major depressive disorder who were not taking medication and levels of dopamine transporter expression in postmortem tissues from donors with major depressive disorder who died by suicide.
This JAMA Network Insights article summarizes 7 evidence-based elements for effectively treating suicidal patients.
This study examines the association between insulin resistance, schizophrenia polygenic risk, and treatment outcomes in first-episode, antipsychotic-naive patients with schizophrenia.
This study evaluates network meta-analyses that combined pharmacological and nonpharmacological interventions.