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Oct 2011

Supplemental Oxygen and Surgical Site Infection—Reply

Arch Surg. 2011;146(10):1221-1223. doi:10.1001/archsurg.2011.291

In reply

We would like to thank Dr Sessler for his interest in our study. We appreciate his criticism, although most of his points were already considered in our article.

The issue of hyperoxygenation and wound site infection is controversial and well discussed in the medical literature. The reasons for a surgical site infection are multifactorial, and the data interpretation can be affected by many factors. Our aim was to further illuminate the subject by choosing to study as homogenous as possible a population of patients with a surgical site infection associated with the right lower incision for acute appendicitis. In light of our introduction and expanded Comment section, we cannot ignore feeling that Dr Sessler's comments regarding the hypothesis and our clinical trial's registration are somehow surprising and “curious.”