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Comment & Response
November 2015

Effect of Gastric Bypass vs Duodenal Switch on High-Density Lipoprotein Cholesterol Level

Author Affiliations
  • 1Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio
JAMA Surg. 2015;150(11):1098-1099. doi:10.1001/jamasurg.2015.1951

To the Editor A recent study by Risstad and colleagues1 assessed the long-term outcomes of Roux-en-Y gastric bypass (RYGB) and biliopancreatic diversion with duodenal switch (BPD-DS) among superobese patients. Sixty patients with a body mass index (calculated as weight in kilograms divided by height in meters squared) of 50 to 60 were enrolled in a well-designed randomized clinical trial (RCT). Five years after surgery, the mean reductions in body mass index were 13.6 and 22.1 after RYGB and BPD-DS, respectively (P < .001). Reductions in the levels of total cholesterol, low-density lipoprotein cholesterol, triglyceride, and fasting glucose were significantly greater after BPD-DS than after RYGB. Conversely, concentrations of high-density lipoprotein cholesterol (HDL-C) increased after both procedures, with larger increases after RYGB (P = .002).1