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Invited Commentary
December 2015

Liver Transplantation for Pediatric Hepatoblastoma and Hepatocellular Carcinoma: Out of the Unknown

Author Affiliations
  • 1Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles
JAMA Surg. 2015;150(12):1158-1159. doi:10.1001/jamasurg.2015.1875

With advances in chemotherapy, surgical treatment, and postoperative care, the prognosis for children with hepatoblastoma (HBL) has improved significantly during the past 3 decades. The combined use of liver transplantation and chemotherapy is now the preferred treatment option for unresectable HBL.1 In pediatric patients with hepatocellular carcinoma (HCC), transplantation has been associated with improved disease-free survival compared with conventional treatment with chemotherapy and resection, particularly in children with advanced-stage tumors or chronic underlying liver disease.2

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