Fong and colleagues report on the “Discordance Between Perioperative Antibiotic Prophylaxis and Wound Infection Cultures in Patients Undergoing Pancreaticoduodenectomy.”1 Their observational study1 is the largest, multi-institutional evaluation of perioperative antibiotic use that is correlated with postoperative wound infections after pancreatoduodenectomy. Interestingly, the wound infection rate is exactly the same despite different prophylactic antibiotic regimens. The authors are to be commended for their great effort in collecting and analyzing data from 1623 patients.