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Comment & Response
August 2016

Management of Acute Appendicitis, Comparative Effectiveness Research, and the Nuances of Study Design—Reply

Author Affiliations
  • 1Center for Surgical Outcomes Research, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio
  • 2Department of Surgery, Nationwide Children’s Hospital, Columbus, Ohio
JAMA Surg. 2016;151(8):784-785. doi:10.1001/jamasurg.2016.0478

In Reply We thank Dr Drake for his insightful comments. As pointed out, our intent was to study the effectiveness of nonoperative management in clinical practice because we believe that the safety and efficacy of antibiotics to treat acute appendicitis are now well established in recent trials and reports.1-3

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