In Reply We thank Dr Drake for his insightful comments. As pointed out, our intent was to study the effectiveness of nonoperative management in clinical practice because we believe that the safety and efficacy of antibiotics to treat acute appendicitis are now well established in recent trials and reports.1-3
Minneci PC, Deans KJ. Management of Acute Appendicitis, Comparative Effectiveness Research, and the Nuances of Study Design—Reply. JAMA Surg. 2016;151(8):784–785. doi:10.1001/jamasurg.2016.0478
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