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Invited Commentary
November 16, 2016

Esophageal Resection for Cancer After Neoadjuvant Chemoradiation: To Wait or Not To Wait?

Author Affiliations
  • 1Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill
JAMA Surg. 2016;151(11):e162750. doi:10.1001/jamasurg.2016.2750

The ideal time interval for esophagectomy after neoadjuvant chemoradiotherapy (CRT) for patients with esophageal cancer is unknown, but in most centers, the operation is usually performed 4 to 8 weeks after CRT when the patient has fully recovered. A similar time interval between CRT and operation has traditionally been accepted for patients with rectal cancer; however, recent studies1,2 have suggested that a longer wait may increase the rate of pathologic complete responses (pCRs) and may improve survival.

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