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Invited Commentary
February 2017

Polyglycolic Acid Mesh in Distal PancreatectomyA Tool for Preventing Postoperative Pancreatic Fistula?

Author Affiliations
  • 1Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles
JAMA Surg. 2017;152(2):156. doi:10.1001/jamasurg.2016.3645

Postoperative pancreatic fistula (POPF) is the most frequent and serious complication following distal pancreatectomy. Various approaches, including different closure methods, transection devices, intestinal serosal patches, fibrin glue, and drainage procedures have been proposed as potential means of preventing POPF.1 Polyglycolic acid (PGA) is a biodegradable thermoplastic polymer being used to facilitate wound healing in tissues ranging from oral mucosa and pleura to dura mater. Polyglycolic acid is hypothesized to induce inflammation and adhesion formation and through this mechanism prevent POPF. Previous case series evaluating the use of PGA mesh for preventing POPF are limited by the retrospective nature and the lack of standardized surgical technique.24

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