The worldwide incidence of intrahepatic cholangiocarcinoma (ICC) is increasing, and the oncological outcomes are far from satisfactory. Lack of both an understanding of its tumor biology and a distinct staging system that gives us accurate prognostic value could be the reason for this disappointing outcome. Therefore, there is a need to develop a solid staging system that provides integrated guidance for the treatment of ICC. Historically, the hepatocellular carcinoma staging system had been applied to ICC until the seventh edition of American Joint Committee on Cancer (AJCC) classification was developed.
Tomiyama K, Hernandez-Alejandro R, Linehan DC. Staging for Intrahepatic Cholangiocarcinoma: Are We Getting Close to Understanding the True Tumor Biology? JAMA Surg. 2017;152(5):e170108. doi:10.1001/jamasurg.2017.0108
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