Intragastric single-port surgery (IGS) is performed by means of exteriorization of the gastric wall through the abdominal wall and placement of a single-port device with intragastric access. It differs from conventional laparoscopic or single-port surgery by the intragastric approach with direct endoluminal visualization of possible tumors and enables intragastric procedures. For instance, gastric tumors in difficult locations, especially at the esophagogastric junction, which are not amendable to endoscopic resection, can be easily visualized and resected.