Preoperative chemotherapy and/or chemoradiation is considered today the standard of care for the treatment of locally advanced/borderline resectable pancreatic cancer (PDAC).1
With this regard, terms such as downstaging and neoadjuvant are commonly reported in medical literature and mutually used as synonyms to address preoperative treatment. A first important issue that should be pointed out is a matter of definitions.
Del Chiaro M, Valente R, Arnelo U. Neoadjuvant Treatment in Locally Advanced and Borderline Resectable Pancreatic Cancer vs Primary Resectable Pancreatic Cancer. JAMA Surg. 2017;152(11):1057. doi:10.1001/jamasurg.2017.2228
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