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Invited Commentary
February 2018

Does Tranexamic Acid Cause Venous Thromboembolism After Trauma?Who Cares, If It Saves Lives?

Author Affiliations
  • 1Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 2Departments of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 3Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 4Armstrong Institute for Patient Safety and Quality, Johns Hopkins Medicine, Baltimore, Maryland
  • 5Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
JAMA Surg. 2018;153(2):175-176. doi:10.1001/jamasurg.2017.3855

Early tranexamic acid (TXA) administration following an injury has decreased mortality rates in both military and civilian populations.1,2 Consequently, TXA is now incorporated as an adjunct to blood product–based “damage control resuscitation” protocols in not only civilian trauma centers, but also in deployed combat casualty care in which the early adoption of TXA was driven by limitations of blood component availability in austere settings.3-7

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