In Reply We appreciate the opportunity to respond to the comments provided by the authors of these 2 letters regarding our article.1 The overall message of the letter from Leeds and Fang seems to be that there are important limitations to consider when using the National Cancer Data Base (NCDB) for research and when interpreting the findings from such studies. Regarding the letter from Renehan et al, the main issue seems to be that contemporary European guidelines contraindicate local excision as a management strategy for squamous cell carcinoma of the anal canal (SCCAC), and they too cite additional limitations associated with the use of NCDB data.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Chai CY, Tran Cao HS, Massarweh NN. Limitations of the National Cancer Data Base to Evaluate Early-Stage Anal Cancer Treatment Outcomes—Reply. JAMA Surg. 2018;153(7):691–692. doi:10.1001/jamasurg.2018.0400
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: