Despite the value of cytologic evaluation of thyroid nodules in reducing the frequency of surgery for benign cases, the challenge of indeterminate nodules, with their 5% to 30% risk of becoming cancerous, remains.1,2 Patients with indeterminate thyroid nodules have typically been recommended for surgery even though most nodules proved to be benign.3 In recent years, a commercially available gene expression classifier (GEC) test with high sensitivity and negative predictive value has been shown to reduce the number of thyroidectomies performed for benign disease.4
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Angelos P. The Problem of the Indeterminate Thyroid Nodule: A Genomic Sequencing Classifier and Clinical Judgment. JAMA Surg. 2018;153(9):824–825. doi:10.1001/jamasurg.2018.1164
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