[Skip to Content]
[Skip to Content Landing]
Views 406
Citations 0
Invited Commentary
September 2018

The Problem of the Indeterminate Thyroid Nodule: A Genomic Sequencing Classifier and Clinical Judgment

Author Affiliations
  • 1Department of Surgery, the University of Chicago, Chicago, Illinois
JAMA Surg. 2018;153(9):824-825. doi:10.1001/jamasurg.2018.1164

Despite the value of cytologic evaluation of thyroid nodules in reducing the frequency of surgery for benign cases, the challenge of indeterminate nodules, with their 5% to 30% risk of becoming cancerous, remains.1,2 Patients with indeterminate thyroid nodules have typically been recommended for surgery even though most nodules proved to be benign.3 In recent years, a commercially available gene expression classifier (GEC) test with high sensitivity and negative predictive value has been shown to reduce the number of thyroidectomies performed for benign disease.4

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words