In this issue of JAMA Surgery, LeMaire et al1 present their findings from a set of experiments performed in a standard animal model of aortic aneurysm and dissection (AAD) that convincingly demonstrates that the addition of ciprofloxacin to a challenge-induced model of AAD is associated with severe aortic destruction, increased incidence of aortic aneurysm, dissection, and death. Importantly, this occurs in multiple different aortic segments (most commonly in the ascending aorta) and in both sexes. The authors then decipher the likely multiple mechanisms by which this occurs in their in vivo model, as well as in experiments using in vitro treatment of aortic smooth muscle cells.
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Upchurch GR. Evidence Against the Use of Fluoroquinolones in Patients With Aortic Pathology. JAMA Surg. Published online September 01, 2018153(9):e181988. doi:10.1001/jamasurg.2018.1988
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