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Comment & Response
December 5, 2018

Addressing Clinical Significance—Reply

Author Affiliations
  • 1Center for Surgery and Public Health, Department of Surgery, Brigham and Women’s Hospital, Boston, Massachusetts
  • 2Deputy Editor, JAMA Surgery
JAMA Surg. Published online December 5, 2018. doi:10.1001/jamasurg.2018.4749

In Reply We thank Webster et al for their thoughtful letter regarding clinical significance of findings from surgical outcomes studies using large data sets. We appreciate their concerns and agree that health scientists should consider both individual-level and population-level implications of their findings when discussing the clinical significance of observational studies using large data sets. Failure to consider the multifaceted implications of such findings may lead to unintended harms when research is used as the basis for changes to clinical practice or health policy.

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