Surgery and pain induce stress and inflammatory responses that have radical effects on cellular and systems physiology, extending well beyond the time of surgery. There is a growing appreciation that, in the same way that mitigating the negative effects of such factors plays an important role in promoting wound healing and preventing complications (such as postoperative infections), surgery, anesthesia, and pain might also be associated with the risk of metastatic recurrence after cancer surgery. Naturally, speculation has followed that modifications of perioperative interventions, such as anesthetic or analgesic technique, may help reduce the postoperative incidence of metastasis and improve patients’ long-term survival.
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Perry NJS, Buggy D, Ma D. Can Anesthesia Influence Cancer Outcomes After Surgery? JAMA Surg. 2019;154(4):279–280. doi:10.1001/jamasurg.2018.4619
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