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Comment & Response
February 20, 2019

Unifying Design and Analysis for Superiority and Noninferiority Trials With Appropriate End Point—Reply

Author Affiliations
  • 1Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
JAMA Surg. 2019;154(5):467-468. doi:10.1001/jamasurg.2018.5858

In Reply In their correspondence, Claggett et al did not comment on the topic of our Research Letter (interpretation of inconclusive noninferiority trials)1 but rather made 2 suggestions regarding the design and analysis of superiority and noninferiority trials. We respectfully disagree with both proposals, particularly in the context of clinical trials in surgery.

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