In Reply In their correspondence, Claggett et al did not comment on the topic of our Research Letter (interpretation of inconclusive noninferiority trials)1 but rather made 2 suggestions regarding the design and analysis of superiority and noninferiority trials. We respectfully disagree with both proposals, particularly in the context of clinical trials in surgery.
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Acuna SA, Dossa F, Baxter NN. Unifying Design and Analysis for Superiority and Noninferiority Trials With Appropriate End Point—Reply. JAMA Surg. 2019;154(5):467–468. doi:10.1001/jamasurg.2018.5858
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