[Skip to Content]
[Skip to Content Landing]
Views 360
Citations 0
Invited Commentary
February 27, 2019

Association of Outcome Definitions With Success Following Adrenalectomy for Primary Aldosteronism

Author Affiliations
  • 1Center of Surgery and Health Economics, Division of Endocrine and Oncologic Surgery, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia
JAMA Surg. 2019;154(4):e185843. doi:10.1001/jamasurg.2018.5843

It has been 6 decades since Conn and Louis1 reported the first case of primary aldosteronism (PA). Now, PA is diagnosed in approximately 10% of patients with hypertension and up to 20% of individuals with resistant hypertension.2,3 Unilateral causes of hyperaldosteronism are potentially surgically curable, and adrenalectomy has been shown to be both cost-effective and to have superior outcomes compared with medical therapy.4,5 Screening is likely underused and clinical outcomes are heterogeneously reported. Greater consciousness of PA and standardized criteria for clinical outcomes therefore has the potential for a substantial effect on public health.

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words
    ×