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Invited Commentary
February 27, 2019

Association of Outcome Definitions With Success Following Adrenalectomy for Primary Aldosteronism

Author Affiliations
  • 1Center of Surgery and Health Economics, Division of Endocrine and Oncologic Surgery, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia
JAMA Surg. 2019;154(4):e185843. doi:10.1001/jamasurg.2018.5843

It has been 6 decades since Conn and Louis1 reported the first case of primary aldosteronism (PA). Now, PA is diagnosed in approximately 10% of patients with hypertension and up to 20% of individuals with resistant hypertension.2,3 Unilateral causes of hyperaldosteronism are potentially surgically curable, and adrenalectomy has been shown to be both cost-effective and to have superior outcomes compared with medical therapy.4,5 Screening is likely underused and clinical outcomes are heterogeneously reported. Greater consciousness of PA and standardized criteria for clinical outcomes therefore has the potential for a substantial effect on public health.

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