To the Editor With great interest, we read the article by Xu et al.1 The authors investigated the risk factors, patterns, and predictors of long-term outcomes in 734 patients with and without late hepatocellular carcinoma (HCC) recurrence after curative resection.
In the statistical analyses, we would like to suggest reanalyzing the data without the 112 patients with late recurrence receiving irregular surveillance to strengthen the results of this study. Those patients were diagnosed as having recurrence because of symptoms. Therefore, they might have had early recurrence if they had received regular surveillance. This might influence the results of the study.
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Okubo K, Moro A, Sasaki K. Care After Liver Resection for Hepatocellular Carcinoma. JAMA Surg. 2019;154(6):568–569. doi:10.1001/jamasurg.2019.0149
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