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Invited Commentary
April 24, 2019

Balancing the Risks and Benefits of Surgical Prophylaxis: Timing and Duration Do Matter

Author Affiliations
  • 1Department of Surgery, Stanford University, Stanford, California
JAMA Surg. 2019;154(7):598-599. doi:10.1001/jamasurg.2019.0570

Surgical site infections (SSIs) are among the most common and costly health care–associated infections.1 While the goal of perioperative antimicrobial prophylaxis is to prevent SSIs, antibiotic misuse is widespread and can have deleterious effects. The unintended consequences of prolonged therapy include drug toxicity, the emergence of Clostridium difficile infections, and antimicrobial resistance.2

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